Chimeric antigen receptor (CAR) T cell therapy has emerged as an important therapeutic option for hematological malignancies.
A sensitive follow-up of patients undergoing CD19-targeted CAR T cell therapy is important to analyze, e.g., the in vivo expansion and persistence of these cells in the context of the clinical response of the patient. Furthermore, down-stream analysis of CAR T cells isolated from the patients’ blood could help identify factors that distinguish responders from non-responders.
In this webinar Prof. Boris Fehse from the University Clinic Hamburg-Eppendorf and Dr. Thomas Stübig from the University Clinic Kiel will give insights into their work.
Following the two presentation there will be time for open questions and discussion with our two presenters.
Monitoring of CD19 CAR T cells by digital PCR and flow cytometry
Presenter: Prof. Dr. Boris Fehse
Immunotherapy with CD19 specific CAR T cells has shown excellent efficacy in late-stage B cell cancers. In vivo expansion and persistence of CAR T cells after infusion are important response- and toxicity-determining variables, but standardized diagnostic tools for CAR T cell monitoring have not been widely implemented outside clinical trials. In this webinar we will report on:
In conclusion, CAR-specific dPCR and FC assays are excellent complementary tools to monitor infused CAR T cells in real-time in different body tissues.
The other side of CAR T-cell research – from bedside to bench side
Presenter: Dr. Thomas Stübig
CAR T cells have changed the treatment of B cell lymphoma and B cell leukemia. As many patients benefit from this innovative therapy approach there is a significant number of patients who are non-responding to CAR T cell treatment. Analyzing CAR T cells could help identify factors that are accountable for response, but also for non-response to this therapy. Three major practical topics on isolating CAR T cells for research use will be discussed:
Since 2009 Full professor, Head of the Research Dept. Cell and Gene Therapy at the Dept. of SCT, UKE, Hamburg, Germany
2007–2008 Head of Experimental Paediatric Oncology and Hematology at the University Hospital of the Goethe University Frankfurt, Germany
1999–2007 Head of Laboratories, Clinic for SCT, UKE, Hamburg, Germany
Since Feb 2020 Senior physician, 2nd Department of Internal Medicine – Hematology /Oncology; Universitätsklinikum Schleswig-Holstein (UKSH), Kiel, Germany
2019–2020 Training and senior physician in palliative care
2017–2019 Senior physician, 2nd Department of Internal Medicine – Hematology /Oncology; Universitätsklinikum Schleswig-Holstein (UKSH), Kiel
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