Clone:
REA814
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IF, IHC
Alternative names:
ZAP-70, SRK

Specifications for ZAP70 Antibody, anti-human, REAfinity™

Overview

Clone REA814 recognizes the human zeta-chain-associated protein kinase 70 (ZAP70). ZAP70 plays an essential role in regulation of the adaptive immune response. It is normally expressed near the surface membrane of T cells and natural killer cells. Zap70 associates with the ζ subunit of the T cell antigen receptor and plays a critical role in T cell–signaling. It regulates both T cell–activation switch on and switch off by modulating TCR expression at the T cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection. Additionally, the ZAP70-dependent signaling pathway may also contribute to primary B cells formation and activation through the B cell receptor. Recruitment and activation of ZAP70 are transient and are terminated by phosphorylation of negative regulatory tyrosine residues and dephosphorylation of positively acting sites.
Additional information: Clone REA814 displays negligible binding to Fc receptors.

Alternative names

ZAP-70, SRK

Detailed product information

Technical specifications

CloneREA814
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse
Cross-reactivitymouse
AntigenZAP70
Alternative names of antigenZAP-70, SRK
Molecular mass of antigen [kDa]70
Distribution of antigenB cells, T cells
Entrez Gene ID7535
RRIDAB_2654297, AB_2654298, AB_2654299, AB_2654296

References for ZAP70 Antibody, anti-human, REAfinity™

Publications

  1. Chan, A. C. et al. (1992) ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain. Cell 71(4): 649-662
  2. Arpaia, E. et al. (1994)
    Defective T cell receptor signaling and CD8
    +
    thymic selection in humans lacking zap-70 kinase.
    Cell 76(5): 947-958

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