Clone:
REAL748
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
Wilms tumor protein, WT33

Specifications for WT1 Antibody, anti-human, REAdye_lease™

Overview

Clone REAL748 is an antibody fragment derived from the full WT1 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL748 recognizes the human WT1 protein, also known as Wilms Tumor Protein 1, WT33 or Wilms tumor suppressor protein. WT1 is a transcription factor containing four zinc fingers with distinct splicing isoforms. It plays an important role in cellular development and cell survival, especially in the development of the urogenital system. Furthermore, WT1 has a tumor suppressor and oncogenic role in tumor formation. WT1 is mainly expressed in kidney and on a subset of hematopoietic cells.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

Wilms tumor protein, WT33

Detailed product information

Technical specifications

CloneREAL748
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
Cross-reactivitymouse
AntigenWT1
Alternative names of antigenWilms tumor protein, WT33
Distribution of antigenkidney
RRIDAB_2857795

References for WT1 Antibody, anti-human, REAdye_lease™

Publications

  1. Smolen, G. A. et al. (2004) SUMO-1 modification of the Wilms' tumor suppressor WT1. Cancer Res. 64(21): 7846-7851
  2. Call, K. M. et al. (1990) Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus. Cell 60(3): 509-520
  3. Hamilton, T. B. et al. (1995) High affinity binding sites for the Wilms' tumour suppressor protein WT1. Nucleic Acids Res. 23(2): 277-284

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