UltraMicroscope II

Light sheet microscopy for 3D imaging and analysis of entire biological systems

Light sheet fluorescence microscopy with the UltraMicroscope II enables you to visualize whole biological systems. Moving the sample through the light sheets allows the generation of sharp and bright 3D images. Whether imaging large tissue samples or even entire organs, you are equipped for the task at hand regardless of the clearing protocol and imaging solution being used.  
This light sheet microscope comes in two configurations: it can be fitted with either the Zoom Body Module for easy handling in a multi-user environment, or the Super Plan Module that can deliver never-before-seen image resolution and quality. The Super Plan Module is also available as an upgrade for your UltraMicroscope II.

Benefits

User friendly

An intuitive design, short training time for new users, and minimal staff support requirements make this light sheet microscope the perfect tool for imaging facilities.

Easy adaptation

Apply any clearing protocol and make use of the automated refractive index compensation to maintain high image quality. 

High flexibility

Benefit from our objective lens series designed and optimized specifically for light sheet imaging. Our modular light sheet technology can be tailored to your needs.

From overview to cellular imaging

Explore cellular details in high resolution without losing sight of the big picture.

Features and Specifications

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  • Hägerling, R. et al. (2013) A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy. EMBO J. 32(5): 629-644
  • Weber, T. G. et al. (2014) Apoptosis Imaging for Monitoring DR5 Antibody Accumulation and Pharmacodynamics in Brain Tumors Noninvasively. Cancer Res. 74(7): 1913-1923
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  • Kirst, C. et al. (2020) Mapping the Fine-Scale Organization and Plasticity of the Brain Vasculature. Cell 180(4): 780-795
  • Renier, N. et al. (2014) iDISCO: A Simple, Rapid Method to Immunolabel Large Tissue Samples for Volume Imaging. Cell 159(4): 896-910
  • Renier, N. et al. (2016) Mapping of Brain Activity by Automated Volume Analysis of Immediate Early Genes. Cell 165(7): 1789-1802
  • Susaki, E. A. et al. (2014) Whole-brain imaging with single-cell resolution using chemical cocktails and computational analysis. Cell 157(3): 726-739
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  • Ye, L. et al. (2016) Wiring and Molecular Features of Prefrontal Ensembles Representing Distinct Experiences. Cell 165(7): 1776-1788
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  • Liebmann, T. et al. (2016) Three-Dimensional Study of Alzheimer’s Disease Hallmarks Using the iDISCO Clearing Method Cell Rep 16(4): 1138-1152
  • Zundler, S. et al. (2017) Three-Dimensional Cross-Sectional Light-Sheet Microscopy Imaging of the Inflamed Mouse Gut. Gastroenterology 153(1): 898-900
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  • Lozovaya, N. et al. (2018) GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease. Nat Commun. 9(1): 1422

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UltraMicroscope II

3D imaging and analysis of entire biological systems

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