Clone:
REA1090
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IF, IHC
Alternative names:
NKX2A, TITF1, TTF1, NKX2-1, NKx2.1, Thyroid transcription factor 1

Specifications for TTF-1 Antibody, anti-human/mouse, REAfinity™

Overview

TTF-1 (thyroid transcripton factor-1, NKX2.1) is a homeodomain-containing transcription factor. It controls cell differentiation of telencephalic cells and is essential for proper ventral forebrain development. Furthermore, it is a key factor in the morphogenesis and differentiation of the thyroid and lung. TTF-1 is detected in primary lung adenocarcinomas and small cell carcinomas and is absent in colon and breast carcinomas. Analysis of TTF-1 expression is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating from other tumors.
Additional information: Clone REA1090 displays negligible binding to Fc receptors.

Alternative names

NKX2A, TITF1, TTF1, NKX2-1, NKx2.1, Thyroid transcription factor 1

Detailed product information

Technical specifications

CloneREA1090
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse
Cross-reactivityrat
AntigenTTF-1
Alternative names of antigenNKX2A, TITF1, TTF1, NKX2-1, NKx2.1, Thyroid transcription factor 1
Molecular mass of antigen [kDa]39(same molecular weight for human and mouse/rat)
Distribution of antigenlung
Entrez Gene ID7080, 21869
RRIDAB_2751476, AB_2751513, AB_2751477, AB_2751514, AB_2751478, AB_2751515, AB_2751479, AB_2751516, AB_2751480, AB_2751517, AB_2751481, AB_2751512

References for TTF-1 Antibody, anti-human/mouse, REAfinity™

Publications

  1. Tanaka, H. et al. (2007) Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1. Cancer Res. 67(13): 6007-6011
  2. Li, Y. et al. (2013) NKX2-1 activation by SMAD2 signaling after definitive endoderm differentiation in human embryonic stem cell. Stem Cells Dev. 22(9): 1433-1442

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