Clone:
RMT1-17
Type of antibody:
Primary antibodies
Isotype:
rat IgG1κ
Applications:
FC
Alternative names:
KIM-1, TIMD-1, HAVcr-1, TIM, TIM1

Specifications for TIM-1 Antibody, anti-mouse

Overview

Clone RMT1-17 recognizes the mouse T-cell immunoglobulin mucin receptor 1 (TIM-1) antigen, a Single-pass type I membrane protein also known as Hepatitis A virus cellular receptor 1 (HAVcr-1) or kidney injury molecule 1 (KIM-1). The TIM gene family is involved in a variety of immunity related processes including T cell proliferation and survival, tissue inflammation, and atopy. In mice, eight TIM genes encode the proteins TIM-1 to TIM-8, whereas only three TIM genes are found in humans encoding TIM-1, TIM-3, and TIM-4. Several lines of evidence suggest that TIM-1 regulates T cell activity in vivo through responses mediated by Th1, Th2, Th17, and regulatory T cells. TIM-1 is recruited to the T cell receptor signaling complex and has a costimulatory role. TIM-1 expression has been demonstrated in epithelial cells, especially those of kidney origin, and is greatly increased in both mouse and human kidneys after injury. While absent on naïve CD4 T cells, TIM-1 expression increases following TCR stimulation to provide positive co-stimulatory signal in T cell proliferation and Th1/Th17 cytokine production.

Alternative names

KIM-1, TIMD-1, HAVcr-1, TIM, TIM1

Detailed product information

Technical specifications

CloneRMT1-17
Clonalitymonoclonal
Isotyperat IgG1κ
Isotype controlIsotype Control Antibody, rat IgG1
Hostrat
Type of antibodyPrimary antibodies
Speciesmouse
AntigenTIM-1
Alternative names of antigenKIM-1, TIMD-1, HAVcr-1, TIM, TIM1
Molecular mass of antigen [kDa]31
Distribution of antigenT cells, epithelial cells, kidney
Entrez Gene ID171283
RRIDAB_2654164, AB_2654165, AB_2654166, AB_2654167, AB_2654168, AB_2654169, AB_2654170, AB_2654163

References for TIM-1 Antibody, anti-mouse

Publications

  1. Angiar, I. S. et al. (2014) TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity. Immunity 40(4): 542-553
  2. Feigelstock, D. et al. (1998) The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor. J. Virol. 72(8): 6621-6628
  3. Moller-Tank, S. et al. (2013) Role of the phosphatidylserine receptor TIM-1 in enveloped-virus entry. J. Virol. 87(15): 8327-8341

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TIM-1 Antibody, anti-mouse

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