Clone:
REA494
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
PIgR3, PIgR-3, hOSCAR

Specifications for OSCAR Antibody, anti-human, REAfinity™

Overview

Clone REA494 recognizes the human osteoclast-associated immunoglobulin-like receptor (OSCAR) antigen, a 45 kDa single-pass type I membrane protein also known as polymeric immunoglobulin receptor 3 (PIgR-3). OSCAR is a member of the leukocyte receptor complex (LRC) protein family and is an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. OSCAR expression is detected in preosteoclasts or mature osteoclasts. Osteoclasts are terminally differentiated leukocytes that erode the mineralized bone matrix. These cells originate from hematopoietic precursors and share a common progenitor with macrophages and dendritic cells. Human OSCAR is also expressed at all stages of myeloid dendritic cell maturation, on
in vitro
derived macrophages, granulocytes, and monocyte derived dendritic cells.
Additional information: Clone REA494 displays negligible binding to Fc receptors.

Alternative names

PIgR3, PIgR-3, hOSCAR

Detailed product information

Technical specifications

CloneREA494
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenOSCAR
Alternative names of antigenPIgR3, PIgR-3, hOSCAR
Molecular mass of antigen [kDa]28
Distribution of antigendendritic cells, macrophages, osteoclasts
Entrez Gene ID126014
RRIDAB_2751733, AB_2653088, AB_2653089, AB_2653090, AB_2653091, AB_2653094, AB_2653095, AB_2751793

References for OSCAR Antibody, anti-human, REAfinity™

Publications

  1. Barrow, A. D. et al. (2011) OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice. J. Clin. Invest. 121(9): 3505-3516
  2. Kim, N. et al. (2002) A novel member of the leukocyte receptor complex regulates osteoclast differentiation. J. Exp. Med. 195(2): 201-209
  3. Goettsch, C. et al. (2011) The osteoclast-associated receptor (OSCAR) is a novel receptor regulated by oxidized low-density lipoprotein in human endothelial cells. Endocrinology 152(12): 4915-4926

Related products for
OSCAR Antibody, anti-human, REAfinity™

2 products available