Clone:
REA582
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
CLEC5A, Mdl1, Ly100, CLECSF5

Specifications for MDL-1 (CLEC5A) Antibody, anti-mouse, REAfinity™

Overview

Clone REA582 recognizes the mouse myeloid DAP12-associating lectin 1 (MDL-1) antigen, also known as C-type lectin domain family 5 member A (CLEC5A) or C-type lectin superfamily member 5 (CLECSF5). MDL-1 is type II transmembrane protein which contains a charged residue in the transmembrane region that enables it to pair with DAP12. MDL-1 is expressed on myeloid cells. It has been suggested, that MDL-1 plays an important role in immune defense as a result of an innate immunity.
Additional information: Clone REA582 displays negligible binding to Fc receptors.

Alternative names

CLEC5A, Mdl1, Ly100, CLECSF5

Detailed product information

Technical specifications

CloneREA582
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenMDL-1 (CLEC5A)
Alternative names of antigenCLEC5A, Mdl1, Ly100, CLECSF5
Molecular mass of antigen [kDa]22
Distribution of antigenmacrophages, monocytes, neutrophils
Entrez Gene ID23845
RRIDAB_2652836, AB_2652837, AB_2652838, AB_2652839

References for MDL-1 (CLEC5A) Antibody, anti-mouse, REAfinity™

Publications

  1. Bakker, A. B. et al. (1999) Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells. Proc. Natl. Acad. Sci. U.S.A. 96(17): 9792-9796
  2. Inui, M. et al. (2009) Signal adaptor DAP10 associates with MDL-1 and triggers osteoclastogenesis in cooperation with DAP12. Proc. Natl. Acad. Sci. U.S.A. 106(12): 4816-4821
  3. Aoki, N. et al. (2009) Expression and functional role of MDL-1 (CLEC5A) in mouse myeloid lineage cells. J. Leukoc. Biol. 85(3): 508-517

Related products for
MDL-1 (CLEC5A) Antibody, anti-mouse, REAfinity™

2 products available

Seems like you are coming from USA!
Do you want to visit our website in your country?