CD197 (CCR7) antibodies, mouse

CD197 (CCR7) antibodies, mouse

Clone: REA685 | Dilution: 1:50
Clone REA685 recognizes the mouse CD197 (CCR7) antigen, a chemokine receptor for chemokines CCL19 and CCL21. CD197, like other chemokine receptors has seven transmembrane spanning domains and signals via G proteins. Expression of CD197 is found on semi-mature and mature dendritic cells (DCs), naive B and T cells, regulatory T (Treg) cells, a subpopulation of T cells called central memory T cells, and non-immune malignant cells. CD197 is involved in regulating homing of immune cells, immunity to pathogens, immune tolerance, development and function of Tregs, and manifestation of autoimmunity.
Additional information: Clone REA685 displays negligible binding to Fc receptors.

Alternative names

C-C chemokine receptor type 7, C-C CKR-7, CC-CKR-7, CCR-7, EBI1, MIP-3 beta receptor, EBI-1

Technical specifications

  • Antigen: CD197 (CCR7)
  • Clone: REA685
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: C-C chemokine receptor type 7, C-C CKR-7, CC-CKR-7, CCR-7, EBI1, MIP-3 beta receptor, EBI-1
  • Entrez Gene ID: 12775
  • Molecular mass of antigen [kDa]: 40
  • Distribution of antigen: dendritic cells, B cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
  • Selected references

    1. Ritter, U. et al. (2004) Analysis of the CCR7 expression on murine bone marrow-derived and spleen dendritic cells. J. Leukoc. Biol. 76(2): 472-476
    2. Bjorkdahl, O. et al. (2003) Characterization of CC-chemokine receptor 7 expression on murine T cells in lymphoid tissues. Immunology 110(2): 170-179
    3. Forster, R. et al. (2008) CCR7 and its ligands: balancing immunity and tolerance. Nat. Rev. Immunol. 8(5): 362-371
Product options: 1
150 µg in 1 mL (1)
EUR  260,00