Anti-WIP pS488 antibodies, human

Anti-WIP pS488 antibodies, human

Clone: REA537 | Dilution: 1:11
Clone REA537 recognizes the human Wiskott-Aldrich syndrome protein-interacting protein (WIP) antigen phosphorylated at serine 488 (pS488). WIP is a multifunctional adaptor implicated in a wide range of cellular functions, including cell adhesion, migration and chemotaxis, T cell activation and proliferation, and intracellular pathogen motility. WIP functions through binding to both globular and filamentous actin and several regulators of actin dynamics. WIP can also bind to and regulate the function of the actin-nucleation-promoting factor cortactin. In cells of haematopoietic origin, WIP is an important regulator of Wiskott-Aldrich syndrome protein (WASP), the expression of which is restricted to cells of this lineage. WASP is indispensable for normal leukocyte function and its importance is highlighted in the congenital disorder Wiskott–Aldrich syndrome in which missense mutations in the WAS gene result in severe immunodeficiency. Phosphorylation represents a strong candidate for regulation of WIP function, as studies have reported serine/threonine phosphorylation of WIP on a number of residues. S488 has been reported to be phosphorylated in a PKCθ-dependent manner in response to T cell receptor activation.
Additional information: Clone REA537 displays negligible binding to Fc receptors.

Alternative names

WIPF1, PRPL-2, WAS2, WASPIP, WIP

Technical specifications

  • Antigen: WIP pS488
  • Clone: REA537
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: WIPF1, PRPL-2, WAS2, WASPIP, WIP
  • Entrez Gene ID: 7456
  • Molecular mass of antigen [kDa]: 51
  • Distribution of antigen: ubiquitous
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected references

    1. Ramesh, N. et al. (1997) WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells. Proc. Natl. Acad. Sci. U.S.A. 94(26): 14671-14676
    2. Vijayakumar, V. et al. (2015) Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophages. J. Cell. Sci. 128(2): 251-265
Product options: 4
for 30
tests
(1)
EUR  120,00
for 100
tests
(1)
EUR  295,00
for 30
tests
(1)
EUR  120,00
for 100
tests
(1)
EUR  295,00

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