Anti-PIR-A/B antibodies, mouse

Clone: REA472 | Dilution: 1:10
Clone REA472 recognizes both isoforms of the mouse paired immunoglobulin-like receptor (PIR-A and PIR-B) antigen, a single-pass type I membrane protein which is also known as leukocyte immunoglobulin-like receptor 3 (LIR-3). Cell surface expression of PIR molecules on myeloid and B lineage cells increase with cellular differentiation and activation. PIR molecules are also expressed on dendritic cells, monocytes/macrophages, and mast cells in varying levels, but not on T cells and NK cells. PIR-A/B is a receptor for class I MHC antigens and down-regulates antigen-induced B cell–activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).
Additional information: Clone REA472 displays negligible binding to Fc receptors.

Alternative names

6M21, Ly89, PIRA1, Pir, GP91, LIR-3, LILRB3, PIR-B

Technical specifications

  • Antigen: PIR-A/B
  • Clone: REA472
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: 6M21, Ly89, PIRA1, Pir, GP91, LIR-3, LILRB3, PIR-B
  • Entrez Gene ID: 18722, 18733
  • Molecular mass of antigen [kDa]: 83
  • Distribution of antigen: B cells, dendritic cells, macrophages, monocytes, mast cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, Biotin
  • Selected references

    1. Kubagawa, H. et al. (1997) A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells. Proc. Natl. Acad. Sci. U.S.A. 94(10): 5261-5266
    2. Bléry, M. et al. (1998) The paired Ig-like receptor PIR-B is an inhibitory receptor that recruits the protein-tyrosine phosphatase SHP-1. Proc. Natl. Acad. Sci. U.S.A. 95(5): 2446-2451
    3. Kubagawa, H. et al. (1999) Biochemical nature and cellular distribution of the paired immunoglobulin-like receptors, PIR-A and PIR-B. J. Exp. Med. 189(2): 309-318
Product options: 8
9 µg in 300 µL (1)
EUR  50,00
30 µg in 1 mL (1)
EUR  115,00
9 µg in 300 µL (1)
EUR  40,00
30 µg in 1 mL (1)
EUR  100,00
9 µg in 300 µL (1)
EUR  50,00
30 µg in 1 mL (1)
EUR  100,00
9 µg in 300 µL (1)
EUR  35,00
30 µg in 1 mL (1)
EUR  60,00

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