Anti-FoxP3 antibodies, mouse

Clone: REA788 | Dilution: 1:50
Clone REA788 recognizes the forkhead/winged-helix transcriptional regulator FoxP3, also known as forkhead box P3, scurfin, or JM2. FoxP3 is expressed pre-dominantly in regulatory T cells (Tregs) and is a major marker and functional regulator of Treg cell development and function. Mutations in the FoxP3 gene are linked to the autoimmune manifestations observed in the Scurfy mouse and humans with immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. Studies in mice have shown that FoxP3-deficient animals lack Treg cells, whereas overexpression of the FoxP3 protein leads to profound immune suppression.
Additional information: Clone REA788 displays negligible binding to Fc receptors.

Alternative names

AIID, DIETER, IPEX, JM2, PIDX, XPID

Technical specifications

  • Antigen: FoxP3
  • Clone: REA788
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: AIID, DIETER, IPEX, JM2, PIDX, XPID
  • Entrez Gene ID: 50943
  • Molecular mass of antigen [kDa]: 47
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Vio515, Vio667
  • Selected references

    1. Sakaguchi, S. et al. (1995) Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155: 1151-1164
    2. Hori, S. et al. (2003) Control of regulatory T cell development by the transcription factor FoxP3. Science 299: 1057-1061
    3. Walker, M. R. et al. (2003)
      Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4
      +
      CD25
      -
      T cells.
      J. Clin. Invest. 112: 1437-1443
    4. Jaeckel, E. et al. (2005) Antigen-specific FoxP3-transduced T-cells can control established type 1 diabetes. Diabetes 54: 306-310
    5. Ziegler, S. F. (2006) FoxP3: of mice and men. Annu. Rev. Immunol. 24: 209-226
    6. Gavin, M. A. et al. (2006) Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proc. Natl. Acad. Sci. U.S.A. 103: 6659-6664
    7. Lamprecht, B. et al. (2008) Aberrant expression of the Tʜ2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3alpha. Blood 112(8): 3339-3347
Product options: 8
30 µg in 200 µL (1)
EUR  90,00
150 µg in 1 mL (1)
EUR  260,00
30 µg in 200 µL (1)
EUR  90,00
150 µg in 1 mL (1)
EUR  260,00
30 µg in 200 µL (1)
EUR  110,00
150 µg in 1 mL (1)
EUR  315,00
30 µg in 200 µL (1)
EUR  110,00
150 µg in 1 mL (1)
EUR  315,00

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