Clone:
4E5
Type of antibody:
Primary antibodies
Isotype:
rat IgG2aκ
Applications:
FC, MICS, IF, IHC
Alternative names:
Klra4, Chok, Klra32, Klra33, Ly-49d

Specifications for Ly-49D Antibody, anti-mouse

Overview

Clone 4E5 recognizes Ly-49D, a type II transmembrane NK-cell receptor belonging to the Ly-49 family. Members of Ly-49 family are homodimeric C-type lectin receptors, recognizing MHC class I molecules as ligands and include activating and inhibitory receptor molecules. Ly-49D is a prototypic activating member of Ly-49 family and in contrast to inhibitory members, lacks a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM). A positive signal is initiated by interaction of Ly-49D with immunoreceptor tyrosine-based activating motif (ITAM) containing transmembrane adapter DAP12. Expression of Ly-49D is strain restricted and is found on subsets of NK cells in C57BL/6, C3H/He, and SJL but not in BALB/c, DBA/2, AKR, and CBA/J mice.

Alternative names

Klra4, Chok, Klra32, Klra33, Ly-49d

Detailed product information

Technical specifications

Clone4E5
Clonalitymonoclonal
Isotyperat IgG2aκ
Isotype controlIsotype Control Antibody, rat IgG2a
Hostrat
Type of antibodyPrimary antibodies
Speciesmouse
AntigenLy-49D
Alternative names of antigenKlra4, Chok, Klra32, Klra33, Ly-49d
Molecular mass of antigen [kDa]31
Entrez Gene ID16635
RRIDAB_2652710, AB_2652711, AB_2652712, AB_2652713, AB_2652714, AB_2652715, AB_2652716, AB_2652717, AB_2652718, AB_2652719, AB_2652720, AB_2652721, AB_2652722, AB_2652723, AB_2652724, AB_2652709

References for Ly-49D Antibody, anti-mouse

Publications

  1. Hanke, T. et al. (1999) Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors. Immunity 11(1): 67-77
  2. Mason, L. H. et al. (1996) The Ly-49D receptor activates murine natural killer cells. J. Exp. Med. 184: 2119-2128
  3. Yokoyama, W. M. et al. (1993) The Ly-49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: the NK gene complex. Annu. Rev. Immunol. 11: 613-635

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