Clone:
REA552
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
Lrp4, CLSS, CMS17, LRP10, MEGF7, SOST2, KIAA0816

Specifications for LRP-4 Antibody, anti-human, REAfinity™

Overview

Clone REA552 recognizes the human LRP-4 antigen, a β-propeller containing protein, which is a member of the low density lipoprotein-receptor gene family and a modulator of extracellular cell signaling pathways in development. LRP-4 is expressed in bone and cultured osteoblasts and binds Dkk1 and sclerostin
in vitro
. It plays a physiological role in the regulation of bone growth and turnover.
Additional information: Clone REA552 displays negligible binding to Fc receptors.

Alternative names

Lrp4, CLSS, CMS17, LRP10, MEGF7, SOST2, KIAA0816

Detailed product information

Technical specifications

CloneREA552
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenLRP-4
Alternative names of antigenLrp4, CLSS, CMS17, LRP10, MEGF7, SOST2, KIAA0816
Molecular mass of antigen [kDa]210
Distribution of antigenosteoblasts, bone
Entrez Gene ID4038
RRIDAB_2652651, AB_2652652, AB_2652653, AB_2652654, AB_2652655, AB_2652656

References for LRP-4 Antibody, anti-human, REAfinity™

Publications

  1. Holdsworth, G. et al. (2012) Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of Wnt co-receptors. J. Biol. Chem. 287(32): 26464-26477
  2. Leupin, O. et al. (2011) Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function. J. Biol. Chem. 286(22): 19489-19500
  3. Choi, H. Y. et al. (2009)
    Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover
    in vivo
    .
    PLoS One 4(11): e7930

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