Clone:
REA748
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
ITGB6, Integrin beta-6

Specifications for Integrin β6 Antibody, anti-human, REAfinity™

Overview

Clone REA748 recognizes the human integrin β6 antigen, a 95 kDa type I transmembrane glycoprotein which is a member of the integrin β family. Integrins are heterodimeric glycoprotein receptors and exist as non-covalently bound α and β subunits. Integrin β6, also known as ITGB6, is a receptor for fibronectin and cytotactin and interacts with coxsackievirus A9 and coxsackievirus B1 proteins. Integrin β6 forms heterodimers with integrin αV. Internalisation of integrin αV/β6 via clathrin-mediated endocytosis promotes carcinoma cell invasion.
Additional information: Clone REA748 displays negligible binding to Fc receptors.

Alternative names

ITGB6, Integrin beta-6

Detailed product information

Technical specifications

CloneREA748
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenIntegrin β6
Alternative names of antigenITGB6, Integrin beta-6
Molecular mass of antigen [kDa]84
Distribution of antigenepithelial cells
Entrez Gene ID3694
RRIDAB_2652493, AB_2652494, AB_2652495, AB_2652496, AB_2652497, AB_2652498, AB_2652499, AB_2652492

References for Integrin β6 Antibody, anti-human, REAfinity™

Publications

  1. Agrez, M. V. et al. (1997) Integrin alpha v beta 6 enhances coxsackievirus B1 lytic infection of human colon cancer cells. Virology 239(1): 71-77
  2. Ramsay, A. G. et al. (2007) HS1-associated protein X-1 regulates carcinoma cell migration and invasion via clathrin-mediated endocytosis of integrin alphavbeta6. Cancer Res. 67(11): 5275-5284
  3. Gianni, T. et al. (2013) αvβ6- and αvβ8-integrins serve as interchangeable receptors for HSV gH/gL to promote endocytosis and activation of membrane fusion. PLoS Pathog. 9(12)

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