Clone REA483 recognizes the human integrin α9β1 antigen, a single-pass type I membrane protein which is also known as integrin alpha-RLC. Integrins are heterodimeric glycoprotein receptors and exist as non-covalently bound α and β subunits. The integrin α9β1 binds a number of extracellular matrix components like VCAM1, cytotactin, and osteopontin to mediate cell adhesion, migration, and tissue invasion. Although widely expressed in a variety of normal human cells including endothelium, different types of muscle cells, hepatocytes, and in the hematopoietic system, it is also expressed in cancer cells. Expression of integrin α9β1 in human cancers appears to correlate with higher grade tumors.
Additional information: Clone REA483 displays negligible binding to Fc receptors.
