Clone:
REA1032
Type of antibody:
Recombinant antibodies, Primary antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
MCGF, MULTI-CSF

Specifications for IL-3 Antibody, anti-human, REAfinity™

Overview

Clone REA1032 recognizes the human interleukin-3 (IL-3) antigen, a secreted molecule which belongs to a discrete family of cytokines that regulates the growth, differentiation, migration, and effector function activities of many hematopoietic cells and immunocytes. IL-3 stimulates the differentiation of multipotent hematopoietic stem cells into myeloid progenitor cells or into lymphoid progenitor cells. In addition, IL-3 stimulates proliferation of all cells in the myeloid lineage (granulocytes, monocytes, and dendritic cells), in conjunction with other cytokines. It is secreted by basophils and activated T cells to support growth and differentiation of T cells from the bone marrow in an immune response. Activated T cells can either induce their own proliferation and differentiation, or that of other T cells.
Additional information: Clone REA1032 displays negligible binding to Fc receptors.

Alternative names

MCGF, MULTI-CSF

Detailed product information

Technical specifications

CloneREA1032
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyRecombinant antibodies, Primary antibodies
Specieshuman
AntigenIL-3
Alternative names of antigenMCGF, MULTI-CSF
Molecular mass of antigen [kDa]15
Distribution of antigenT cells
Entrez Gene ID3562
RRIDAB_2784382, AB_2784383

References for IL-3 Antibody, anti-human, REAfinity™

Publications

  1. Baxter, E. W. et al. (2012) The inducible tissue-specific expression of the human IL-3/GM-CSF locus is controlled by a complex array of developmentally regulated enhancers. J. Immunol. 189(9): 4459-4469
  2. Yang, Y. C. et al. (1986) Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3. Cell 47(1): 3-10
  3. Broughton, S. E. et al. (2012) The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling. Immunol. Rev. 250(1): 277-302

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