Alternative names:

Specifications for Human RANK-Ligand – soluble


RANK-Ligand - soluble stands for receptor activator of NF-κB ligand, soluble. Human RANK-Ligand - soluble is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.


Human RANK-Ligand – soluble can be used for a variety of applications, including:
  • In vitro differentiation of monocytes to osteoclasts, together with M-CSF.
  • Study of cell-receptor signaling of tumor necrosis factor receptor family.
  • Investigation in immune cell activation, osteogenesis, and tumor growth.

Alternative names


Detailed product information

Background information

Receptor activator of nuclear factor kappa-B (RANK) ligand, also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), together with RANK, is a member of the TNF superfamily of ligands and receptors involved in activation of immune response and in bone regeneration. RANK-Ligand is expressed in several tissues and cell types, including fibroblasts, T cells, and osteoblasts, and functions by binding its cell surface signaling receptor RANK. RANK-Ligand is expressed by T helper cells and is involved in dendritic cell maturation. Binding of osteoprotegerin (OPG) by RANK-Ligand inhibits osteoclastogenesis and leads to accumulation of bone and cartilage. High expression of RANK-Ligand is observed during degenerative bone diseases and in tumors. Human RANK-Ligand shares with mouse 85% amino acid identity and is reactive on murine cells.

Quality description

cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Resources for Human RANK-Ligand – soluble


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