IL-9 stands for interleukin 9. Human IL-9 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Specifications for Human IL-9

Overview

IL-9 stands for interleukin 9. Human IL-9 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human IL-9 can be used for a variety of applications, including:
  • T cell stimulation
  • Mast cell activation

Detailed product information

Background information

Interleukin 9 (IL-9) belongs to the common cytokine receptor γ-chain-dependent family, together with IL-2, IL-4, IL-7, IL-15, and IL-21. It is secreted by stimulated T helper cells, and specifically by a subpopulation classified as Tʜ9 cells. The IL-9 receptor forms a complex that internalizes upon IL-9 binding, and it is expressed both as a membrane-bound and a soluble form. In combination with other immune-stimulatory cytokines, IL-9 acts as a mitogen of lymphoid cells and other immune cells, such as erythroid precursors, mast cells, Tʜ2 cells and eosinophils. Moreover, IL-9 regulates hematopoietic cell differentiation, increases immunoglobulin production, and induces the growth of lymphoma and other T cell-mediated tumors. Mouse and human IL-9 share only a partial homology. Whereas mouse IL-9 is effective on human cells, human IL-9 is inactive in murine cell culture.

Biological activity

  • Proliferation of human MO7e cells
  • research grade: ≥ 1.4×
    10
    6
    U/mg

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Resources for Human IL-9

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

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