BMP-7 stands for bone morphogenetic protein 7. Human BMP-7 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Specifications for Human BMP-7

Overview

BMP-7 stands for bone morphogenetic protein 7. Human BMP-7 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human BMP-7 can be used for a variety of applications, including:
  • Mesenchymal cell cultures.
  • In vitro studies of bone and cartilage development.
  • Investigation of SMAD signaling.

Detailed product information

Background information

Bone morphogenetic protein 7 (BMP-7) belongs to the BMP family and to the transforming growth factor β (TGF-β) superfamily. BMPs regulate bone and cartilage development and remodeling, acting on cell proliferation, differentiation, and apoptosis of mesenchymal cells. The mature form of BMP-7 is generated by cleavage of the signal peptide and propeptide, and homo-dimerization. BMP-7 is involved in osteoblast differentiation, but also in the regulation of tissue and organ development during embryogenesis of different species, and it is expressed in many organs. BMP-7 is extensively investigated for clinical applications, and recombinant BMP-7 is used in bone regeneration, bone graft, and dental reconstruction. Recombinant Human BMP-7 corresponds to the mature form of BMP-7.

Biological activity

  • Alkaline phosphatase activity assay using MC3T3-E1 cells
  • research grade: ≥ 2.5×
    10
    4
    U/mg

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Resources for Human BMP-7

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

Seems like you are coming from USA!
Do you want to visit our website in your country?