Alternative names:
TNFSF13B, BLys

Specifications for Human BAFF

Overview

BAFF stands for B cell activating factor, also termed BLys. Human BAFF is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human BAFF can be used for a variety of applications, including:
  • Study of B cell differentiation and activation.
  • Investigation of TNF-receptor superfamily signaling.

Alternative names

TNFSF13B, BLys

Detailed product information

Background information

B cell activating factor (BAFF) is a ligand belonging to the TNF superfamily and plays an important role in regulation of lymphocytes, especially peripheral B cells. It is expressed in T cells, dendritic cells, macrophages, and monocytes and binds three receptors, TACI, BCMA, and the BAFF specific receptor (BAFF-R), which is essential for the B cell promoting activity. BAFF induces stimulation of B and T cell function, and promotes maturation and survival of B cell lineage cells and peripheral B cells. High expression of BAFF increases Tʜ1 response, and correlates with B cell malignancies and autoimmunity, such as systemic lupus erythematosus and rheumatoid arthritis, allograft reactions, and celiac disease. On the contrary, inefficient production of BAFF can lead to an impair of B cell activation and immunodeficiency. Recombinant human BAFF contains the TNF-like portion of the extracellular domain, which shares 72% amino acid sequence identity with mouse BAFF.

Biological activity

  • Mouse splenocyte survival assay
  • research grade: ≥ 0.5×
    10
    3
    U/mg

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Resources for Human BAFF

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

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