Clone REAL1173 is an antibody fragment derived from the full Glucagon antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL1173 recognizes human Glucagon, also known as GCG, which is predominantly secreted from the alpha cells of the pancreas. Glucogon is cleaved into 8 chains and plays a key role in glucose metabolism and homeostasis. Glucagon is stimulated by hypoglycemia and inhibited by hyperglycemia, insulin, and somatostatin. It raises plasma glucose levels in response to insulin-induced hypoglycemia and therfore is important in initiating and maintaining hyperglycemic conditions in diabetes. Used to treat severe hypoglycemia in insulin-dependent diabetics.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).
