CliniMACS Prodigy® Instrument

Automated cell processing in a closed system

The CliniMACS Prodigy represents the next generation in automated cell processing. This device offers advanced integrated solutions to streamline cell processing workflows – from cell separation through cell culture to formulation of the final product.

The CliniMACS Prodigy offers a flexible platform for cell processing applications enabling the magnetic separation of different cell types as well as customized cell processing protocols. The cell processing unit for fully automated washing, fractionation and cultivation of cells represents an integral component of the device. These processing steps take place in a single-use chamber, which is included as part of specific CliniMACS Prodigy Tubing Sets. The magnetic cell separation unit comprises a second integral component, enabling the separation of virtually any cell type.

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Benefits

Automation

Ensuring standardized GMP-compliant cell products over and over again

Closed system

Reduced cleanroom requirements as well as increased product and operator safety

Scalability

Reproducible processes across multiple instruments supporting centralized and decentralized manufacturing models

Flexibility 

Timely and safe cell manufacturing procedures with flexible protocol software for different cell types

Features & specifications

CliniMACS prodigy

CentriCult Unit (CCU)

Temperature controlled unit for cell processing and cell cultivation

Peristaltic pump

Directs accurate volumes of liquids through the tubing set

Pinch valves

Ensure controlled fluid pathways within the tubing set

Touchscreen

Software guides the operator through interactions

Magnet unit

Houses the separation column for magnetically labelled cell enrichment

Gas mix unit

Mixes up to three gases for cell cultivation

     

CentriCult Unit (CCU)

Temperature controlled unit for cell processing and cell cultivation

Peristaltic pump

Directs accurate volumes of liquids through the tubing set

Pinch valves

Ensure controlled fluid pathways within the tubing set

Touchscreen

Software guides the operator through interactions

MiniSampler

Magnet unit

Houses the separation column for magnetically labelled cell enrichment

MiniSampler

Gas mix unit

Mixes up to three gases for cell cultivation

CliniMACS prodigy
Video

CliniMACS Prodigy - Automated cell processing in a closed system

The CliniMACS Prodigy® is a closed and automated platform that streamlines GMP-compliant cell manufacturing.

Brochures/posters

Scientific posters

App notes/customer reports

References

  • Lock, D. et al. (2017) Automated manufacturing of potent CD20-directed chimeric antigen receptor T cells for clinical use. Hum. Gene Ther. 28(10): 914-925
  • Klöß, S et al. (2017) Optimization of human NK cell manufacturing: Fully automated separation, improved ex vivo expansion using IL-21 with autologous feeder cells, and generation of Anti-CD123-CAR-expressing effector cells. Hum. Gene Ther. 28(10): 897-913
  • Editorial (2017) The key to unlocking CARs. Nat. Biotechnol. 35(10): 889
  • Tarnowski, J. et al. (2017) Delivering advanced therapies: the big pharma approach. Gene Ther. 24(9): 593-598
  • Fraser, A. R. et al. (2017) Development, functional characterization and validation of methodology for GMP-compliant manufacture of phagocytic macrophages: A novel cellular therapeutic for liver cirrhosis. Cytotherapy 19(9): 1113-1124
  • Pello, O. M. et al. (2017) BKV-specific T cells in the treatment of severe refractory haemorrhagic cystitis after HLA-haploidentical haematopoietic cell transplantation. Eur. J. Haematol. 98(6): 632-634
  • Skorska, A. et al. (2017) GMP-conformant on-site manufacturing of a CD133(+) stem cell product for cardiovascular regeneration. Stem Cell Res. Ther. 8(1): 33
  • Levine, B. L. et al. (2016) Global manufacturing of CAR T cell therapy. Mol. Ther. Methods Clin. Dev. 4: 92-101
  • Priesner, C. et al. (2016) Automated enrichment, transduction and expansion of clinical-scale CD62L+ T cells for manufacturing of GTMPs. Hum. Gene Ther. 27(10): 860-869
  • Priesner, C. et al. (2016) Comparative analysis of clinical-scale IFN-γ-positive T cell enrichment using partially and fully integrated platforms. Front Immunol 7: 393
  • Mock, U. et al. (2016) Automated manufacturing of chimeric antigen receptor T cells for adoptive immunotherapy using CliniMACS prodigy. Cytotherapy 18(8): 1002-1011
  • Takashi, I. et al. (2016) Multiple allogeneic progenitors in combination function as a unit to support early transient hematopoiesis in transplantation. J. Exp. Med. 213(9): 1865-1880
  • Wang, X. and Rivière, I. (2016) Clinical manufacturing of CAR T cells: foundation of a promising therapy. Mol. Ther. Oncolytics 3: 16015
  • Walker, A. and Johnson, R. (2016) Commercialization of cellular immunotherapies for cancer. Biochem. Soc. Trans. 44(2): 329-332
  • Hümmer, C. et al. (2016) Automation of cellular therapy product manufacturing: results of a split validation comparing CD34 selection of peripheral blood stem cell apheresis product with a semi-manual vs. an automatic procedure. J. Transl. Med. 14: 76
  • Stroncek, D. F. et al. (2016) Preliminary evaluation of a highly automated instrument for the selection of CD34+ cells from mobilized peripheral blood stem cell concentrates. Transfusion 56(2): 511-517
  • Bunos, M. et al. (2015) Automated isolation of primary antigen-specific T cells from donor lymphocyte concentrates: results of a feasibility exercise. Vox sang. 109(4): 387-393
  • Spohn, G. et al. (2015) Automated CD34+ cell isolation of peripheral blood stem cell apheresis product. Cytotherapy 17(10): 1465-1471
  • Kumaresan, P. et al. (2015) Automated cell enrichment of cytomegalovirus-specific T cells for clinical applications using the cytokine-capture system. J. Vis. Exp. 104: e52808
  • Sorg, N. et al. (2015) Red blood cell depletion from bone marrow and peripheral blood buffy coat: a comparison of two new and three established technologies. Transfusion 55(6): 1275-1282
  • Granzin, M. et al. (2015) Fully automated expansion and activation of clinical-grade natural killer cells for adoptive immunotherapy. Cytotherapy 17(5): 631-632
  • Apel, M. et al. (2013) Integrated clinical scale manufacturing system for cellular products derived by magnetic cell separation, centrifugation and cell culture. Chemie Ingenieur Technik 85: 103-110

Applications

A wide variety of cell processing applications are supported by the CliniMACS Prodigy platform. Learn more about the highlighted applications below or get an overview of the full potential of the platform and all available workflows by visiting our clinical application page.

Software

The CliniMACS Prodigy Software makes your work easier

  • Standard processes - Prodigy operating system comes with pre-programed verified application specific processes 
  • Customizable – providing modularity and flexible programming 
  • Comparable, standardized results and multi-instrument alignment for scaling out of manufacturing
  • Log reports of processes

Support

Support at your fingertips

  • CliniMACS technical support for real-time assistance from our experts
  • Technical and field application support for application design
  • Instrument training at regional Miltenyi University facilities
  • Comprehensive service options provided by our globally distributed field service teams

CliniMACS Prodigy® Instrument

Automated cell processing in a closed system 
Order no. 200-075-301 

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