Clone:
REA1190
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
B7-2, B70, CLS1, Cd28l2, ETC-1, Ly-58, MB7-2, TS/A-2

Specifications for CD86 Antibody, anti-mouse, REAfinity™

Overview

Clone REA1190 recognizes the mouse CD86 antigen, also known as B7-2, an 80 kDa molecule and a member of the immunoglobulin superfamily. Together with CD80 (B7-1) it belongs to the B7 family of costimulatory molecules. CD86 is expressed on activated antigen-presenting cells, including B cells, dendritic cells, and monocytes/macrophages. The interaction of CD86 with its ligands CD28 and CD152 (CTLA- 4) plays a critical role in induction and regulation of immune responses, e.g., cross-talk between T and B cells, T cell costimulation, or immunoglobulin class-switching. Binding of CD86 to CD28 on T cells results in transduction of costimulatory signals for activation or proliferation of T cells, or cytokine production. In contrast, binding of CD86 to CTLA-4 regulates T cell activation and diminishes the immune response.
Additional information: Clone REA1190 displays negligible binding to Fc receptors.

Alternative names

B7-2, B70, CLS1, Cd28l2, ETC-1, Ly-58, MB7-2, TS/A-2

Detailed product information

Technical specifications

CloneREA1190
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD86
Alternative names of antigenB7-2, B70, CLS1, Cd28l2, ETC-1, Ly-58, MB7-2, TS/A-2
Molecular mass of antigen [kDa]32
Distribution of antigenB cells, dendritic cells, macrophages, monocytes, other
Entrez Gene ID12524
RRIDAB_2819413, AB_2819414, AB_2819412

Resources for CD86 Antibody, anti-mouse, REAfinity™

Certificates

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References for CD86 Antibody, anti-mouse, REAfinity™

Publications

  1. Kin, N. W. et al. (2006) CD86 stimulation on a B cell activates the phosphatidylinositol 3-kinase/Akt and phospholipase C gamma 2/protein kinase C alpha beta signaling pathways. J. Immunol. 176(11): 6727-6735
  2. Nakajima, A. et al. (1997) Requirement of CD28-CD86 co-stimulation in the interaction between antigen-primed T helper type 2 and B cells. Int. Immunol. 9(5): 637-644
  3. Zhu, X. Y. et al. (2005)
    Blockade of CD86 signaling facilitates a Tʜ2 bias at the maternal-fetal interface and expands peripheral CD4
    +
    CD25
    +
    regulatory T cells to rescue abortion-prone fetuses.
    Biol. Reprod. 72(2): 338-345

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