Clone:
REA983
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
B7-1, Cd28l, Ly-53, Ly53, MIC17, TSA1, B7, BB1

Specifications for CD80 Antibody, anti-mouse, REAfinity™

Overview

Clone REA983 recognizes the mouse CD80 antigen also known as B7, B7-1, or Ly-53. The 55 kDa member of the Ig superfamily is expressed on activated B cells, macrophages, and dendritic cells. The interaction of CD80 and CD152 (CTLA-4) or CD28 induces T cell proliferation and cytokine production.
Additional information: Clone REA983 displays negligible binding to Fc receptors.

Alternative names

B7-1, Cd28l, Ly-53, Ly53, MIC17, TSA1, B7, BB1

Detailed product information

Technical specifications

CloneREA983
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse, other
Cross-reactivitydog
AntigenCD80
Alternative names of antigenB7-1, Cd28l, Ly-53, Ly53, MIC17, TSA1, B7, BB1
Molecular mass of antigen [kDa]30
Distribution of antigenB cells, dendritic cells, Langerhans cells, macrophages, monocytes, T cells, Langerhans cells
Entrez Gene ID12519
RRIDAB_2727513, AB_2727557, AB_2727514, AB_2727558, AB_2727515, AB_2727563, AB_2727520, AB_2727559, AB_2727516, AB_2727560, AB_2727517, AB_2727561, AB_2727518, AB_2727562, AB_2727519, AB_2727556

References for CD80 Antibody, anti-mouse, REAfinity™

Publications

  1. Razi-Wolf, Z. et al. (1992) Expression and function of the murine B7 antigen, the major costimulatory molecule expressed by peritoneal exudate cells. Proc. Natl. Acad. Sci. U.S.A. 89: 4210 -4214
  2. Harlan, D. M. et al. (1994) Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness. Proc. Natl. Acad. Sci. U.S.A. 91: 3137-3141
  3. Hathcock, K. S et al. (1994) Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function. J. Exp. Med. 180(2): 631-640
  4. Bluestone, J. A. et al. (1995) New perspectives of CD28-B7-mediated T cell costimulation. Immunity 2(6): 555-559

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