Clone:
REA237
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC

Specifications for CD68 Antibody, anti-rat, REAfinity™

Overview

Clone REA237 recognizes rat CD68, also known as macrosialin, which is a heavily glycosylated type I transmembrane protein of the LAMP (lysosomal-associated membrane protein) family. CD68 is expressed by the majority of tissue macrophages and weakly by peripheral blood granulocytes. It is also present on rat Kupffer cells but absent from rat liver endothelial cells. The expression of rat CD68 is predominantly intracellular, but it is reported that weak cell surface expression also occurs as well. CD68 functions as a macrophage receptor for oxidized low density lipoprotein.
Additional information: Clone REA237 displays negligible binding to Fc receptors.

Detailed product information

Technical specifications

CloneREA237
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesrat
AntigenCD68
Molecular mass of antigen [kDa]35
Distribution of antigenmacrophages, monocytes
Entrez Gene ID287435
RRIDAB_2659011, AB_2659012, AB_2659015, AB_2659016, AB_2659017, AB_2659018

References for CD68 Antibody, anti-rat, REAfinity™

Publications

  1. Rabinowitz, S. S. et al. (1991) Macrosialin, a macrophage-restricted membrane sialoprotein differentially glycosylated in response to inflammatory stimuli. J. Exp. Med. 174(4): 827-836
  2. Van Velzen, A. G. et al. (1997) Characterization of a receptor for oxidized low-density lipoproteins on rat Kupffer cells: similarity to macrosialin. Biochem. J. 1(322): 411-415

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