Clone:
REA300
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
DAF, Daf-GPI, Daf1, GPI-DAF

Specifications for CD55 (DAF) Antibody, anti-mouse, REAfinity™

Overview

Clone REA300 recognizes the CD55 antigen, a glycoprotein also known as complement decay-accelerating factor (DAF). There are two mouse CD55 genes, which share 85% nucleotide and 78% amino acid identities, and have been designated CD55-glycosylphosphatidylinositol and CD55-transmembrane to reflect the two alternate mechanisms of membrane attachment. Both proteins are recognized by clone REA300. CD55 is broadly distributed among hematopoietic and non-hematopoietic cells. It is expressed on the plasma membranes of all cell types that are in intimate contact with serum and it is also found on the surfaces of epithelial cells, lining extracellular compartments. CD55 plays multiple physiologic roles including tissue protection from the cytotoxic complement injury, anti-inflammatory function owing to its anti-adherence properties which enhance transmigration of monocytes and macrophages and reduce tissue injury. CD55 plays an essential role during pregnancy and is involved in the protection of the semiallogeneic fetus and in preventing uncontrolled infiltration by white cells. It is exploited in multiple pathologic conditions by pathogens and viruses in chronic tissue infection processes.
Additional information: Clone REA300 displays negligible binding to Fc receptors.

Alternative names

DAF, Daf-GPI, Daf1, GPI-DAF

Detailed product information

Technical specifications

CloneREA300
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD55 (DAF)
Alternative names of antigenDAF, Daf-GPI, Daf1, GPI-DAF
Molecular mass of antigen [kDa]36
Distribution of antigenepithelial cells
Entrez Gene ID13136
RRIDAB_2658706, AB_2658707, AB_2658708, AB_2658709, AB_2658710, AB_2658711, AB_2658712, AB_2658713, AB_2658714, AB_2658715

References for CD55 (DAF) Antibody, anti-mouse, REAfinity™

Publications

  1. Spicer, A. P. et al. (1995) Molecular cloning and chromosomal localization of the mouse decay-accelerating factor genes. Duplicated genes encode glycosylphosphatidylinositol-anchored and transmembrane forms. J. Immunol. 155(6): 3079-3091
  2. Fukuoka, Y. et al. (1996) Molecular cloning of murine decay accelerating factor by immunoscreening. Int. Immunol. 8(3): 379-385
  3. Harris, C. L. et al. (1999) Molecular and functional analysis of mouse decay accelerating factor (CD55). Biochem. J. 341: 821-829

Related products for
CD55 (DAF) Antibody, anti-mouse, REAfinity™

2 products available