Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Alternative names:
L3T4, T4, Leu-3, Ly-4

Specifications for CD4 Antibody, anti-mouse, REAdye_lease™


Clone REAL130 is an antibody fragment derived from the full CD4 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL130 recognizes the mouse CD4 antigen, a cell surface glycoprotein, which is a member of the immunoglobulin superfamily. It is also known as L3T4 or Leu-3. In mice, CD4 is expressed on T helper cells, regulatory T cells, and at lower levels on subpopulations of NKT cells and dendritic cells. It is furthermore detected on most thymocytes (CD4+CD8+ and CD4+CD8– thymocytes). CD4 interacts with MHC class II molecules on the surface of antigen presenting cells. It increases the avidity of the interaction between T cells and antigen-presenting or target cells.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

L3T4, T4, Leu-3, Ly-4

Detailed product information

Technical specifications

Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Alternative names of antigenL3T4, T4, Leu-3, Ly-4
Distribution of antigenT cells, dendritic cells, NKT cells, thymocytes, CD4+ T cells

Resources for CD4 Antibody, anti-mouse, REAdye_lease™


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References for CD4 Antibody, anti-mouse, REAdye_lease™


  1. Tourvieille, B. et al. (1986) Isolation and sequence of L3T4 complementary DNA clones: expression in T cells and brain. Science 234(4776): 610-614
  2. Parnes, J. R. et al. (1987) L3T4 and the immunoglobulin gene superfamily: new relationships between the immune system and the nervous system. Immunol. Rev. 100: 109-127
  3. Bierer, B. E. et al. (1989) The biologic roles of CD2, CD4, and CD8 in T-cell activation. Annu. Rev. Immunol. 7: 579-599
  4. Birjandi, S. Z. et al. (2016) CD4(+)CD25(hi)Foxp3(+) Cells Exacerbate Bleomycin-Induced Pulmonary Fibrosis. Am. J. Pathol. 186(8): 2008-2020

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