Specifications for CD371 (CLEC12A) Antibody, anti-mouse, REAfinity™
Overview
Clone REA594 recognizes the mouse CD371 (CLEC12A) antigen, a 30 kDa type II transmembrane protein with extracellular C-type lectin domains. CD371 (CLEC12A) is a member of the C-type lectin/C-type lectin–like domain (CTL/CTLD) superfamily which have a common protein fold and plays a role in cell adhesion, cell-cell signaling, glycoprotein turnover, inflammation, and immune response.CD371 expression is primarily found on granulocytes and monocytes but also on CD8
+ dendritic cells (DCs), plasmacytoid DCs, granulocytes, and B cells. It associates with the signaling phosphatases SHP-1 and SHP-2, but not with SHIP and is a negative regulator of granulocyte and monocyte function.
Additional information: Clone REA594 displays negligible binding to Fc receptors.
Alternative names
CLL-1, MICL, DCAL-2Detailed product information
Technical specifications
| Clone | REA594 |
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| Clonality | monoclonal |
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| Isotype | recombinant human IgG1 |
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| Isotype control | REA Control Antibody, human IgG1 |
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| Host | human cell line |
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| Type of antibody | Primary antibodies, Recombinant antibodies |
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| Species | mouse |
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| Antigen | CD371 (CLEC12A) |
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| Alternative names of antigen | CLL-1, MICL, DCAL-2 |
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| Molecular mass of antigen [kDa] | 31 |
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| Distribution of antigen | B cells, dendritic cells, granulocytes, monocytes |
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| Entrez Gene ID | 232413 |
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| RRID | AB_2657814, AB_2657815, AB_2657816, AB_2657817, AB_2657818, AB_2657819, AB_2657820, AB_2657813 |
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