Clone:
REAL447
Type of antibody:
Releasable antibodies, Primary antibodies, Recombinant antibodies
Applications:
FC
Alternative names:
CD300LE, CLM-2, CMRF35-A5, IREM-2, PIgR-2, LMIR6

Specifications for CD300e (IREM-2) Antibody, anti-human,
REAlease
®

Overview

Clone REAL447 is an antibody fragment derived from the full CD300e (IREM-2) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity.
Clone REAL447 recognizes the human CD300e, also known as IREM-2, LMIR6, or CMRF35-A5. This 34 kDa activating receptor of the immunglobulin superfamily is expressed on mature myeloid dendritic cells and monocytes and is down-regulated on immature dendritic cells. CD300e interacts with DAP-12, which mediates acivating signals. It is reported that the alloreactive response of naive T cells is enhanced by IREM-2 activation of mDCs.
The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes.

Alternative names

CD300LE, CLM-2, CMRF35-A5, IREM-2, PIgR-2, LMIR6

Detailed product information

Technical specifications

CloneREAL447
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable antibodies, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenCD300e (IREM-2)
Alternative names of antigenCD300LE, CLM-2, CMRF35-A5, IREM-2, PIgR-2, LMIR6
Distribution of antigendendritic cells, monocytes, myeloid cells, myeloid dendritic cells
RRIDAB_2802041, AB_2802040

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