Clone:
11F8
Type of antibody:
Primary antibodies
Isotype:
rat IgG2a
Applications:
ICFC, MICS, IF, IHC
Alternative names:
TLR3

Specifications for CD283 (TLR3) Antibody, anti-mouse

Overview

Clone 11F8 recognizes CD283 antigen, which is also known as toll-like receptor 3 (TLR3). Toll-like receptors are a family of pattern recognition receptors that have evolved to detect components of foreign pathogens referred to as pathogen associated molecular patterns. TLR3 is a single-pass type I membrane protein expressed exclusively in intracellular vesicles, such as the endoplasmic reticulum (ER), endosomes, lysosomes, and endolysosomes, where it recognizes microbial dsRNA. Multiple cell types are known to express TLR3 including dendritic cells, keratinocytes, and neurons. TLR3 activates antiviral immune responses via the TRIF-dependent pathway and eventually through the production of type I interferon and inflammatory cytokines, suggesting that TLR3 has an essential role in the prevention of viral infection.

Alternative names

TLR3

Detailed product information

Technical specifications

Clone11F8
Clonalitymonoclonal
Isotyperat IgG2a
Isotype controlIsotype Control Antibody, rat IgG2a
Hostrat
Type of antibodyPrimary antibodies
Speciesmouse
AntigenCD283 (TLR3)
Alternative names of antigenTLR3
Molecular mass of antigen [kDa]101
Distribution of antigendendritic cells
Entrez Gene ID142980
RRIDAB_2656981, AB_2656982, AB_2656983, AB_2656984, AB_2656985, AB_2656986, AB_2656987, AB_2656980

References for CD283 (TLR3) Antibody, anti-mouse

Publications

  1. Doyle, S. E. et al. (2003) Toll-like receptor 3 mediates a more potent antiviral response than Toll-like receptor 4. J. Immunol. 170(7): 3565-3571
  2. Alexopoulou, L. et al. (2001) Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413(6587): 732-738
  3. Applequist, S. E. et al. (2002) Variable expression of Toll-like receptor in murine innate and adaptive immune cell lines. Int. Immunol. 14(9): 1065-1074

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