Clone:
MIH18
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC, MICS, IF, IHC
Alternative names:
PDCD1LG2, B7-DC, Btdc, CD273, PD-L2, PDCD1L2, PDL2

Specifications for CD273 (PD-L2) Antibody, anti-human

Overview

Clone MIH18 recognizes human CD273, also known as B7-DC and PD-L2. CD273 with an approximate molecular weight of 25 kDa is a type I transmembrane protein, belonging to the B7 family of protein ligands and to the Ig superfamily. CD273 is mainly expressed on dendritic cells (DCs) and activated macrophages. It has been shown to interact with programmed-death-receptor 1 (PD-1). Both a stimulatory and inhibitory role of CD273, in T cell activation has been proposed.

Alternative names

PDCD1LG2, B7-DC, Btdc, CD273, PD-L2, PDCD1L2, PDL2

Detailed product information

Technical specifications

CloneMIH18
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenCD273 (PD-L2)
Alternative names of antigenPDCD1LG2, B7-DC, Btdc, CD273, PD-L2, PDCD1L2, PDL2
Molecular mass of antigen [kDa]29
Distribution of antigendendritic cells, macrophages
Entrez Gene ID80380
RRIDAB_2656870, AB_2656871, AB_2656872, AB_2656873, AB_2752180, AB_2656862, AB_2656863, AB_2656864, AB_2656865, AB_2656866, AB_2656867, AB_2752199

References for CD273 (PD-L2) Antibody, anti-human

Publications

  1. Tseng, S. Y. et al. (2001)
    B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells.
    J. Exp. Med. 193: 839-846
  2. Pfistershammer, K. et al. (2006) No evidence for dualism in function and receptors: PD-L2/B7-DC is an inhibitory regulator of human T cell activation. Eur. J. Immunol. 36(5): 1104-1113
  3. Greenwald, R. J. et al. (2005) The B7 family revisited. Annu. Rev. Immunol. 23: 515-548

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