Clone:
DJR3
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC
Alternative names:
TNFRSF10C, DCR1, DCR1-TNFR, LIT, TRAIL-R3, TRAILR3, TRID

Specifications for CD263 (TRAIL-R3) Antibody, anti-human

Overview

Clone DJR3 recognizes the human CD263 antigen, a glycophospholipid-anchored cell membrane protein which is also known as TNF-related apoptosis-inducing ligand receptor 3 (TRAIL-R3) or tumor necrosis factor receptor superfamily member 10C (TNFRSF10C). CD263 is the receptor for the cytotoxic ligand TRAIL. It lacks a cytoplasmic death domain shared by several members of the TNF receptor superfamily and hence is not capable of inducing apoptosis. CD263 is highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung, and heart. It is higher expressed in normal tissues than in tumor cell lines.

Alternative names

TNFRSF10C, DCR1, DCR1-TNFR, LIT, TRAIL-R3, TRAILR3, TRID

Detailed product information

Technical specifications

CloneDJR3
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenCD263 (TRAIL-R3)
Alternative names of antigenTNFRSF10C, DCR1, DCR1-TNFR, LIT, TRAIL-R3, TRAILR3, TRID
Molecular mass of antigen [kDa]22
Distribution of antigenlymphocytes
Entrez Gene ID8794
RRIDAB_2876903, AB_2656758, AB_2656759, AB_2656760, AB_2656761, AB_2876902

References for CD263 (TRAIL-R3) Antibody, anti-human

Publications

  1. Mongkolsapaya, J. et al. (1998) Lymphocyte inhibitor of TRAIL (TNF-related apoptosis-inducing ligand): a new receptor protecting lymphocytes from the death ligand TRAIL. J. Immunol. 160(1): 3-6
  2. Degli-Esposti, M. A. et al. (1997) Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family J. Exp. Med. 186(7): 1165-1170
  3. Ursini-Siegel, J. et al. (2007) Elevated expression of DecR1 impairs ErbB2/Neu-induced mammary tumor development Mol. Cell. Biol. 27(18): 6361-6371