Clone:
CARL-1
Type of antibody:
Primary antibodies
Isotype:
mouse IgG3κ
Applications:
FC
Alternative names:
TNFSF12, APO3L, Dr3lg, TWEAK

Specifications for CD255 (TWEAK) Antibody, anti-human

Overview

Clone CARL-1 reacts with the type II transmembrane protein CD255, also known as TWEAK, belonging to the TNF superfamily. It exists as membrane-bound and secreted form and is expressed on most tissues but not or weakly on hematopoietic lineage lines. TWEAK interacts with its receptor APO-3, which promotes inerleukin 8 (IL-8) secretion, activation of NF-κB, and endothelial cell proliferation and apoptosis.

Alternative names

TNFSF12, APO3L, Dr3lg, TWEAK

Detailed product information

Technical specifications

CloneCARL-1
Clonalitymonoclonal
Isotypemouse IgG3κ
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenCD255 (TWEAK)
Alternative names of antigenTNFSF12, APO3L, Dr3lg, TWEAK
Molecular mass of antigen [kDa]27
Entrez Gene ID8742
RRIDAB_2656695, AB_2656694

References for CD255 (TWEAK) Antibody, anti-human

Publications

  1. Kaplan, M. J. et al. (2000)
    TRAIL (Apo2 Ligand) and TWEAK (Apo3 Ligand) mediate CD4
    +
    T cell killing of antigen-presenting macrophages.
    J. Immunol. 164: 2897- 2904
  2. Chicheportiche, Y. et al. (1997) TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. J. Biol. Chem. 272: 32401 -32410
  3. Lynch, C. N. et al. (1999) TWEAK induces angiogenesis and proliferation of endothelial cells. J. Biol. Chem. 274: 8455-8459

Related products for
CD255 (TWEAK) Antibody, anti-human

1 products available