Type of antibody:
Primary antibodies
mouse IgG2b
Alternative names:
IL-2Rα, p55, Tac

Specifications for CD25 antibodies


4E3 recognizes the human CD25 antigen, a 55 kDa glycoprotein also known as the low-affinity interleukin-2 receptor alpha chain (IL-2Rα). CD25 is expressed on activated T and B cells, on macrophages, and on a subset of non-activated CD4
regulatory T cells. The CD25 antigen contains three epitope regions called A, B, and C. This CD25 antibody recognizes epitope region B.

Alternative names

IL-2Rα, p55, Tac

Detailed product information

Technical specifications

Isotypemouse IgG2b
Type of antibodyPrimary antibodies
Alternative names of antigenIL-2Rα, p55, Tac
Molecular mass of antigen [kDa]28
Distribution of antigenB cells, macrophages, monocytes, NK cells, osteoblasts, T cells

Resources for CD25 antibodies


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References for CD25 antibodies


  1. Sakaguchi, S. et al. (1995) Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155: 1151-1164
  2. Lamprecht, B. et al. (2008) Aberrant expression of the Tʜ2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3alpha. Blood 112(8): 3339-3347
  3. Maloy, K. J. et al. (2001) Regulatory T cells in the control of immune pathology. Nat Immunol 2(9): 816-822
  4. Shevach, E. M. (2001)
    Certified professionals: CD4
    suppressor T cells.
    J. Exp. Med. 193(11): F41-F46
  5. Stelzer, G. T. et al. (1997) U.S.-Canadian consensus recommendations on the immunophenotypic analysis of hematologic neoplasia by flow cytometry: standardization and validation of laboratory procedures. Cytometry 30(5): 214-230
  6. Rothe, G et al. (2012) Consensus protocol for the flow cytometric Immunophenotyping of hematopoietic malignancies. Leukemia 10(5): 877-895
  7. van Dongen, J. J. M. et al. (2012) EuroFlow antibody panels for standardized n-dimensional flow cytometric immunophenotyping of normal, reactive and malignant leukocytes. Leukemia 26(9): 1908-1975
  8. Knapp, W. et al. (eds) Leukocyte Typing IV. Oxford, Oxford University Press
  9. Chaput, N. et al. (2013)
    Phase I clinical trial combining imatinib mesylate and IL-2: HLA-DR
    NK cell levels correlate with disease outcome.
    Oncoimmunology 2(2): e23080
  10. Clinical and Laboratory Standards Institute (CLSI) (2007) Clinical Flow Cytometric Analysis of Neoplastic Hematolympoid Cells, CLSI document H43-A2 (ISBN 1-56238-635-2). CLSI; Approved Guideline - Second Edition
  11. Clinical and Laboratory Standards Institute (CLSI) (2007) Enumeration of immunologically defined cell populations by flow cytometry, CLSI document H42-A2 (ISBN 1-56238-640-9). CLSI; Approved Guideline - Second Edition
  12. Wood, B. L. et al. (2007) 2006 Bethesda International Consensus recommendations on the immunophenotypic analysis of hematolymphoid neoplasia by flow cytometry: optimal reagents and reporting for the flow cytometric diagnosis of hematopoietic neoplasia. Cytometry B Clin. Cytom. 72: 14-22

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