Clone:
REA469
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
MC, FC
Alternative names:
CCR9, CC-CKR-9, CDw199, GPR-9-6, GPR28

Specifications for CD199 (CCR9) Antibody, anti-human, REAfinity™

Overview

Clone REA469 recognizes the human CD199 antigen, a multi-pass membrane protein which is also known as C-C chemokine receptor type 9 (CCR9) or G-protein coupled receptor 28 (GPR28). CD199 is a receptor for the chemokine thymus-expressed chemokine (TECK) and a member of the G protein coupled receptor family (GPCR). The main function of GPCR family members is to send signals into the cell after the activation of G-proteins and they are known for their roles in inflammation, leukocyte trafficking, and immune differentiation. CD199 subsequently transduces a signal by increasing the intracellular calcium ions level. It influences T cell development at several stages within the thymus. In peripheral blood, CD199 is expressed by naive CD8
+
T cells, but not by naive CD4
+
T cells. It is furthermore selectively expressed on plasmacytoid dendritic cells of immature phenotype
in vivo
. Different studies have shown the involvement of the CD199-TECK axis in colorectal, prostate, ovarian, and breast cancers.
Additional information: Clone REA469 displays negligible binding to Fc receptors.

Alternative names

CCR9, CC-CKR-9, CDw199, GPR-9-6, GPR28

Detailed product information

Technical specifications

CloneREA469
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD199 (CCR9)
Alternative names of antigenCCR9, CC-CKR-9, CDw199, GPR-9-6, GPR28
Molecular mass of antigen [kDa]42
Distribution of antigendendritic cells, T cells, thymocytes, T helper cells
Entrez Gene ID10803
RRIDAB_2655985, AB_2655986, AB_2655987, AB_2655988, AB_2655989, AB_2655990, AB_2655991, AB_2655992, AB_2655993, AB_2655994, AB_2655995, AB_2655996, AB_2801902

Resources for CD199 (CCR9) Antibody, anti-human, REAfinity™

References for CD199 (CCR9) Antibody, anti-human, REAfinity™

Publications

  1. Zaballos, A. et al. (1999) Cutting Edge: Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK. J. Immunol. 162(10): 5671-5675
  2. Hadeiba, H. et al. (2008) CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease. Nat. Immunol. 9: 1253-1260
  3. Zhang, Z. et al. (2014) CCR9 as a prognostic marker and therapeutic target in hepatocellular carcinoma. Oncol. Rep. 31(4): 1629-1636

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