Clone:
REA208
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC, MC
Alternative names:
CXCR2, CDw128b, CMKAR2, IL8R2, IL8RA, CD128b, IL-8RB

Specifications for CD182 (CXCR2) Antibody, anti-human, REAfinity™

Overview

Clone REA208 recognizes CD182 (CXCR2), which belongs to the class of chemokine receptors specific for CXC chemokines. Chemokine receptors are G-coupled protein receptors (GPCR) with seven-transmembrane domains and consist of an α-subunit and a βγ-complex. In humans, interleukin 8 (IL-8) is one of most potent chemokine which binds to CXCR2. Expression of CD182 is found on several cell types including leukocytes, endothelial, and epithelial cells. CD182 plays a critical role in neutrophil homeostatis, angiogenesis, and in pathological conditions such as acute lung injury, lung diseases, and asthma.
Additional information: Clone REA208 displays negligible binding to Fc receptors.

Alternative names

CXCR2, CDw128b, CMKAR2, IL8R2, IL8RA, CD128b, IL-8RB

Detailed product information

Technical specifications

CloneREA208
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD182 (CXCR2)
Alternative names of antigenCXCR2, CDw128b, CMKAR2, IL8R2, IL8RA, CD128b, IL-8RB
Distribution of antigenendothelial cells, epithelial cells
RRIDAB_2751974, AB_2752003, AB_2751972, AB_2733102, AB_2733103, AB_2801896, AB_2655723, AB_2655724, AB_2655725, AB_2655726, AB_2655729, AB_2655730, AB_2752004

Resources for CD182 (CXCR2) Antibody, anti-human, REAfinity™

References for CD182 (CXCR2) Antibody, anti-human, REAfinity™

Publications

  1. Belperio, J. A. et al. (2005) CXCR2/CXCR2 ligand biology during lung transplant ischemia-reperfusion injury. J. Immunol. 175: 6931-6939
  2. Thatcher, T. H. et al. (2005) Role of CXCR2 in cigarette smoke-induced lung inflammation. Am. J. Physiol. Lung Cell Mol. Physiol. 289: L322-L328

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