Clone REA1112 recognizes the human CD18 antigen, a type I transmembrane protein with an approximate molecular weight of 90–95 kDa. It non-covalently associates with α subunits CD11a (αL), CD11b (αM), CD11c (αX), and CD11d (αD) to form functional integrins which are expressed on leukocytes. CD18 associated integrins bind several ligands including cell surface and extracellular matrix proteins and are involved in cell-cell and cell-extracellular matrix interactions, immune regulation, and immune tolerance. Leucocytes of patients lacking CD18 or expressing dysfunctional CD18 are defective in chemotaxis, phagocytosis, and homotypic aggregation.
Additional information: Clone REA1112 displays negligible binding to Fc receptors.
