Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Alternative names:
MCAM, MUC18, Endo-CAM, Mel-CAM, S-endo

Specifications for CD146 (MCAM) Antibody, anti-human, REAdye_lease™


Clone REAL1221 is an antibody fragment derived from the full CD146 (MCAM) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL1221 recognizes the human CD146 (MCAM) antigen, also known as MUC18, Mel-CAM, and S-Endo-1. CD146 (MCAM) is a transmembrane glycoprotein belonging to the immunoglobulin superfamily and contains five extracellular immunoglobulin (Ig)-like domains. CD146 (MCAM) possesses a limited tissue expression distribution, including endothelial cells, pericytes, smooth muscle cells, follicular dendritic cells, melanoma cells, and a sub-population of activated T lymphocytes. CD146 (MCAM) is also expressed on marrow stromal cells (MSCs). CD146 (MCAM) functions as a Ca2+-independent cell adhesion molecule that is involved in heterophilic cell-cell interactions, and may be involved in the extravasion and/or homing of activated T cells. CD146 (MCAM) expression in melanoma is also directly associated with tumor growth and metastasis.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

MCAM, MUC18, Endo-CAM, Mel-CAM, S-endo

Detailed product information

Technical specifications

Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
AntigenCD146 (MCAM)
Alternative names of antigenMCAM, MUC18, Endo-CAM, Mel-CAM, S-endo
Distribution of antigenT cells, endothelial cells, dendritic cells, melanoma, smooth muscle, melanoma

Resources for CD146 (MCAM) Antibody, anti-human, REAdye_lease™


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References for CD146 (MCAM) Antibody, anti-human, REAdye_lease™


  1. Pickl, W. F. et al. (1997) MUC18/MCAM (CD146), an activation antigen of human T lymphocytes. J Immunol 158: 2107-2115
  2. Shih, J. M. (1999) The role of CD146 (Mel-CAM) in biology and pathology. J Pathol 189(1): 4-11
  3. Bardin, N. et al. (2001) Identification of CD146 as a component of the endothelial junction involved in the control of cell-cell cohesion. Blood 98: 3677-3684
  4. Satyamoorthy, K. et al. (2001) Mel-CAM-specific genetic suppressor elements inhibit melanoma growth and invasion through loss of gap junctional communication. Oncogene 20: 4676-4684
  5. Yan, Y. et al. (2003) Pathogenesis of autoimmunity after xenogeneic thymus transplantation. J Immunol 170: 5936-5946
  6. Mueller, I. et al. (2006) Animal serum-free culture conditions for isolation and expansion of multipotent mesenchymal stromal cells from human BM. Cytotherapy 8: 437-444

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