Clone:
REA313
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
IL2RG, CIDX, IL-2RG, IMD4, p64, SCIDX, SCIDX1

Specifications for CD132 Antibody, anti-human, REAfinity™

Overview

Clone REA313 recognizes the human CD132 antigen, a 65–70 kDa single-pass type I membrane protein also known as common γ chain, which is shared by the IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 receptors. CD132 is expressed on T and B lymphocytes, NK cells, monocytes, and granulocytes. CD132 is involved in intracellular signal transduction by associating with effector molecules within the cytoplasm. The most common form of severe combined immune deficiency in humans, with lack of circulating T cells, a normal or increased number of B lymphocytes, and an X-linked pattern of inheritance (XSCID) has been shown to be due to defects of the CD132 gene.
Additional information: Clone REA313 displays negligible binding to Fc receptors.

Alternative names

IL2RG, CIDX, IL-2RG, IMD4, p64, SCIDX, SCIDX1

Detailed product information

Technical specifications

CloneREA313
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD132
Alternative names of antigenIL2RG, CIDX, IL-2RG, IMD4, p64, SCIDX, SCIDX1
Molecular mass of antigen [kDa]40
Distribution of antigenB cells, T cells, monocytes, lymphocytes, NK cells, granulocytes
Entrez Gene ID3561
RRIDAB_2819743, AB_2857598, AB_2857810, AB_2857800, AB_2654873, AB_2654874, AB_2654877, AB_2654878, AB_2819748

References for CD132 Antibody, anti-human, REAfinity™

Publications

  1. Ramsey, C. et al. (2008) The lymphopenic environment of CD132 (common gamma-chain)-deficient hosts elicits rapid homeostatic proliferation of naive T cells via IL-15. J. Immunol. 180(8): 5320-5326
  2. Russell, S. M. et al. (1993) Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science 262(5141): 1880-1883
  3. Takesita, T. et al. (1992) Cloning of the gamma chain of the human IL-2 receptor. Science 257(5068): 379-382

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