Specifications for CD117 Antibody, anti-human, REAfinity™
Overview
Clone REA996 recognizes the human CD117 antigen, also known as c-kit or SCF receptor. CD117 is a 145 kDa receptor tyrosine kinase involved in stem cell signaling, activation, and proliferation. It is expressed on about 1–3% of peripheral blood mononuclear cells (PBMCs) and cord blood cells and on up to 10% of bone marrow cells. CD117 is further expressed on basophils, myeloid dendritic cells, TCRα/β
+ T cells, CD19
+ B cells, and CD56
+ NK cells, as well as on mast cells, melanocytes, and acute myeloid leukemia (AML) blasts.
Additional information: Clone REA996 displays negligible binding to Fc receptor.
Alternative names
c-kit, KIT, PBT, SCFRDetailed product information
Technical specifications
| Clone | REA996 |
|---|
| Clonality | monoclonal |
|---|
| Isotype | recombinant human IgG1 |
|---|
| Isotype control | REA Control Antibody (S), human IgG1 |
|---|
| Host | human cell line |
|---|
| Type of antibody | Primary antibodies, Recombinant antibodies |
|---|
| Species | human |
|---|
| Antigen | CD117 |
|---|
| Alternative names of antigen | c-kit, KIT, PBT, SCFR |
|---|
| Molecular mass of antigen [kDa] | 107 |
|---|
| Distribution of antigen | B cells, endothelial cells, fibroblasts, mast cells, megakaryocytes, NK cells, red blood cells, T cells, stem cells, hematopoietic stem and progenitor cells, leukemia cells, cancer stem cells, basophils, myeloid dendritic cells, bone marrow, brain, kidney |
|---|
| Entrez Gene ID | 3815 |
|---|
| RRID | AB_2727619, AB_2727665, AB_2727620, AB_2727666, AB_2727621, AB_2727667, AB_2727622, AB_2922321, AB_2922315, AB_2922320, AB_2922314, AB_2727664 |
|---|
