Clone:
429 (MVCAM.A)
Type of antibody:
Primary antibodies
Isotype:
rat IgG2aκ
Applications:
FC, MICS, IF, IHC
Alternative names:
VCAM1, INCAM-100

Specifications for CD106 (VCAM-1) Antibody, anti-mouse

Overview

Clone 429 (MVCAM.A) recognizes the mouse CD106 antigen, a 110 kDa single chain type I glycoprotein, also known as vascular cell adhesion protein 1 (VCAM-1). CD106 is expressed on bone marrow stromal cells and inflamed vascular endothelium as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Upregulation of CD106 in endothelial cells by inflammatory stimuli and cytokines occurs as a result of increased gene transcription. Primarily, CD106 is an endothelial ligand for very late antigen-4 (VLA-4) or integrin α-4/β-7 and mediates both adhesion and signal transduction. The interactions play a pathophysiologic role in leukocyte adhesion, transmigration, and co-stimulation of T cell proliferation.

Alternative names

VCAM1, INCAM-100

Detailed product information

Technical specifications

Clone429 (MVCAM.A)
Clonalitymonoclonal
Isotyperat IgG2aκ
Isotype controlIsotype Control Antibody, rat IgG2a
Hostrat
Type of antibodyPrimary antibodies
Speciesmouse
AntigenCD106 (VCAM-1)
Alternative names of antigenVCAM1, INCAM-100
Molecular mass of antigen [kDa]79
Distribution of antigenendothelial cells
Entrez Gene ID22329
RRIDAB_2654452, AB_2654453, AB_2654454, AB_2654455, AB_2654456, AB_2654457, AB_2654458, AB_2654451

References for CD106 (VCAM-1) Antibody, anti-mouse

Publications

  1. Kumar, A. G. et al. (1994) Murine VCAM-1. Molecular cloning, mapping, and analysis of a truncated form J. Immunol. 153(9): 4088-4098
  2. Kokovay, E. et al. (2012) VCAM1 is essential to maintain the structure of the SVZ niche and acts as an environmental sensor to regulate SVZ lineage progression Cell Stem Cell 11(2): 220-230
  3. Ou, R. et al. (2008) Regulation of immune response and inflammatory reactions against viral infection by VCAM-1. J. Virol. 82(6): 2952-2965

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