Clone:
REAL845
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
Beta-2-microglobulin, B2M, β2M, CDABP0092, HDCMA22P

Specifications for β2 Microglobulin Antibody, anti-human, REAdye_lease™

Overview

Clone REAL845 is an antibody fragment derived from the full β2 Microglobulin antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL845 recognizes the β2 microglobulin, also known as B2M. β2 microglobulin is a component of the class I major histocompatibility complex (MHC), which is located on all nucleated cells, excluding red blood cells. β2 microglobulin plays a role in the presentation of peptide antigens to the immune system. It has no transmembrane region and binds to the alpha chain of MHC class I molecules and additionally to other class I-like molecules such as CD1 and Qa. β2 microglobulin is a positive marker for multiple myeloma and lymphoma, rheumatoid arthritis, systemic lupus erythematosus, and for inflammatory disorders and viral infections, including HIV and CMV.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

Beta-2-microglobulin, B2M, β2M, CDABP0092, HDCMA22P

Detailed product information

Technical specifications

CloneREAL845
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
Antigenβ2 Microglobulin
Alternative names of antigenBeta-2-microglobulin, B2M, β2M, CDABP0092, HDCMA22P
Distribution of antigenleukocytes, platelets, endothelial cells, epithelial cells, tonsil

References for β2 Microglobulin Antibody, anti-human, REAdye_lease™

Publications

  1. Sreejit, G. et al. (2014) The ESAT-6 protein of Mycobacterium tuberculosis interacts with beta-2-microglobulin (β2M) affecting antigen presentation function of macrophage. PLoS Pathog. 10(10): e1004446
  2. Li, L. et al. (2016) The ESAT-6 protein of Mycobacterium tuberculosis interacts with beta-2-microglobulin (β2M) affecting antigen presentation function of macrophage. Chin. Med. J. 129(4): 448-455

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