Clone:
REAL1032
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
Beta-actin, ACTB

Specifications for β-Actin Antibody, anti-human, REAdye_lease™

Overview

Clone REAL1032 is an antibody fragment derived from the full β-Actin antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL1032 recognizes β-Actin, which belongs to the actin family of highly conserved globular multi-functional proteins that play a role in various types of cell motility. They are able to form microfilaments and are found in all eukaryotic cells. β-Actin is a nonmuscle cytoskeletal actin and exists in most cell types as a component of the cytoskeleton and as a mediator of internal cell motility. Mutatations in this gene may be associated with diffuse large B- cell lymphoma.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

Beta-actin, ACTB

Detailed product information

Technical specifications

CloneREAL1032
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
Cross-reactivitymouse, rat
Antigenβ-Actin
Alternative names of antigenBeta-actin, ACTB
Distribution of antigenany cell type, smooth muscle

References for β-Actin Antibody, anti-human, REAdye_lease™

Publications

  1. Lohr, J. G. et al. (2012) Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing. Proc. Natl. Acad. Sci. U.S.A. 109(10): 3879-3884
  2. Gunning, P. W. et al. (2015) The evolution of compositionally and functionally distinct actin filaments. J. Cell. Sci. 128(11): 2009-2019
  3. Hanukoglu, I. et al. (1983) Complementary DNA sequence of a human cytoplasmic actin. Interspecies divergence of 3' non-coding regions. J. Mol. Biol. 163(4): 673-678