CD96 (TACTILE) antibodies, human

CD96 (TACTILE) antibodies, human

Clone: REA195 | Dilution: 1:11
Clone REA195 recognizes CD96, which is also known as T cell–activated increased late expression (TACTILE). CD96 is a single-pass transmembrane glycoprotein belonging to the Ig superfamily and consists of three extracellular Ig-like domains and a membrane proximal region rich in proline/serine/threonine. Expression of CD96 is found on T cells, NK cells, and on majority of CD34
+
CD38
-
acute myeloid leukemic (AML) cells. CD96 interacts with CD155, which is also known as polio virus receptor and promotes NK cell adhesion to target cells expressing CD155. CD96 is further described as a tumor marker for T cell–acute lymphoblastic leukemia (T-ALL) and AML.
Additional information: Clone REA195 displays negligible binding to Fc receptors.

Alternative names

TACTILE

Technical specifications

  • Antigen: CD96 (TACTILE)
  • Clone: REA195
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: TACTILE
  • Distribution of antigen: T cells, NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Biotin

Specificity

In order to compare the epitope specificity of REAfinity Clone REA195 with other known clones, a competition assay was performed. 
 Cells were incubated with an excess of purified unconjugated REAfinity Antibody followed by staining with fluorochrome-conjugated antibodies of other known clones against the same marker. Based on the fluorescence signal obtained, the clones were identified as recognizing completely overlapping (++), partially overlapping (+), or completely different epitopes (-) of the marker.
 

Other clonesOverlap in epitope recognition with REA195
NK92.39++
  • Selected references

    1. Fuchs, A. et al. (2004) Cutting Edge: CD96 (Tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155). J. Immunol. 172: 3994-3998
    2. Meyer, D. et al. (2009) CD96 interaction with CD155 via its first Ig-like domain is modulated by alternative splicing or mutations in distal Ig-like domains. J. Biol. Chem. 284: 2235-2244
Product options: 6
130-101-036

CD96 (TACTILE)-PE, human

for 30
tests
(1)
DKK 900,00 
130-101-032

CD96 (TACTILE)-PE, human

for 100
tests
(1)
DKK 2.200,00 
130-101-031

CD96 (TACTILE)-APC, human

for 30
tests
(1)
DKK 1.130,00 
130-101-028

CD96 (TACTILE)-APC, human

for 100
tests
(1)
DKK 2.450,00 
130-111-923

CD96 (TACTILE)-Biotin, human

for 30
tests
(1)
DKK 750,00 
130-111-751

CD96 (TACTILE)-Biotin, human

for 100
tests
(1)
DKK 1.850,00