CD87 antibodies, mouse

CD87 antibodies, mouse

Clone: REA630 | Dilution: 1:10
Clone REA630 recognizes the mouse CD87 antigen, a key molecule involved in invasive migration of angiogenic endothelium, also known as uPAR. CD87 binds uPA (urokinase plasminogen activator) and thus facilitates the catalytic C domain of the uPA to come in close proximity of membranebound plasminogen. uPA is a serine protease, which converts plasminogen into plasmin which in turn is involved in digestion of various extracellular matrix proteins. CD87 belongs to the Ly6/neurotoxin receptor family and consists of three disulfide-bonded homologous domains, D1, D2, and D3. Function of uPAR is modulated by two inhibitors, PA1 and PA2. CD87 is expressed in angiogenic endothelial cells.
Additional information: Clone REA630 displays negligible binding to Fc receptors.

Alternative names

U-PAR, uPAR

Technical specifications

  • Antigen: CD87
  • Clone: REA630
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: U-PAR, uPAR
  • Entrez Gene ID: 18793
  • Molecular mass of antigen [kDa]: 30
  • Distribution of antigen: endothelial cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, Biotin
  • Selected references

    1. Suh, T. T. et al. (1994) The murine urokinase-type plasminogen activator receptor gene. J. Biol. Chem. 269(42): 25992-25998
    2. Miljkovic-Licina, M. et al. (2009) Sushi repeat protein X-linked 2, a novel mediator of angiogenesis. FASEB J. 23(12): 4105-4116
    3. Lin, L. et al. (2010) Structure-based engineering of species selectivity in the interaction between urokinase and its receptor: implication for preclinical cancer therapy. J. Biol. Chem. 285(14): 10982-10992
Product options: 8
130-109-899

CD87-VioBright FITC, mouse

9 µg in 300 µL (1)
DKK 430,00 
130-109-857

CD87-VioBright FITC, mouse

30 µg in 1 mL (1)
DKK 850,00 
130-109-897

CD87-PE, mouse

9 µg in 300 µL (1)
DKK 300,00 
130-109-855

CD87-PE, mouse

30 µg in 1 mL (1)
DKK 650,00 
130-109-898

CD87-APC, mouse

9 µg in 300 µL (1)
DKK 430,00 
130-109-856

CD87-APC, mouse

30 µg in 1 mL (1)
DKK 650,00 
130-109-896

CD87-Biotin, mouse

9 µg in 300 µL (1)
DKK 170,00 
130-109-854

CD87-Biotin, mouse

30 µg in 1 mL (1)
DKK 350,00