CD49d antibodies, mouse

CD49d antibodies, mouse

Clone: R1-2 | Dilution: 1:50
The monoclonal antibody R1-2 reacts with mouse CD49d, a 150 kDa Integrin family member, also known as integrin α4 chain. Integrins are cell-surface receptors, expressed as heterodimers essential in various processes mediating intercellular or cell-matrix interaction. CD49d associates non-covalently with the integrin ß or ß1 (CD29) forming the complex VLA4, which is expressed on peripheral lymphocytes, thymocytes, eosinophils, basophils, mast cells, dendritic cells, and monocytes. VLA4 plays a critical role in adhesion and migration of cells into tissues by binding to its ligand VCAM-1 (CD106). Together with the ß7 integrin, CD49d forms the heterodimer LPAM-1, which is a ligand for the mucosal vascular addressin (MAdCAM-1).

Alternative names

ITGA4, Itga4B, VLA-4α

Technical specifications

  • Antigen: CD49d
  • Clone: R1-2
  • Isotype: rat IgG2bκ
  • Isotype control: Rat IgG2b – isotype control antibodies
  • Alternative names of antigen: ITGA4, Itga4B, VLA-4α
  • Entrez Gene ID: 16401
  • Molecular mass of antigen [kDa]: 111
  • Distribution of antigen: B cells, basophils, cardiac muscle, dendritic cells, eosinophils, Langerhans cells, lymphocytes, macrophages, mast cells, monocytes, myeloid cells, NK cells, placenta, red blood cells, skeletal muscle, smooth muscle, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC-Vio770
  • Selected references

    1. Fogler, W. E. et al. (1996) NK cell infiltration into lung, liver, and subcutaneous B16 melanoma is mediated by VCAM-1/VLA-4 interaction. J. Immunol. 156(12): 4707-4714
    2. Vermeulen, M. et al. (1998) Role of adhesion molecules in the homing and mobilization of murine hematopoietic stem and progenitor cells. Blood 92(3): 894-900
    3. Jia, G. Q. et al. (1999) Selective eosinophil transendothelial migration triggered by eotaxin via modulation of Mac-1/ICAM-1 and VLA-4/VCAM-1 interactions. Int. Immunol. 11(1): 1-10
    4. Berlin, C. et al. (1993) Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell 74(1): 185-195
    5. Chacko, S. M. et al. (1989) Identification of a murine Peyer's patch-specific lymphocyte homing receptor as an integrin molecule with an alpha chain homologous to human VLA-4 alpha. Cell 56(1): 37-46
Product options: 2
30 µg in 200 µL (1)
DKK 850,00 
150 µg in 1 mL (1)
DKK 2.450,00 

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