CD243 (ABCB1) antibodies, human

CD243 (ABCB1) antibodies, human

Clone: REA495 | Dilution: 1:11
Clone REA495 recognizes the human CD243 antigen, a multi-pass membrane protein which is also known as multidrug resistance protein 1 (MDR1), ATP-binding cassette sub-family B member 1 (ABCB1), or P-glycoprotein 1. CD243 is a member of the ATP-binding cassette (ABC) transporter superfamily and plays an important role in the development of multidrug resistance (MDR) in cancer cells. This transporter utilizes energy from ATP hydrolysis for the efflux of a variety of chemically dissimilar amphipathic compounds, including anticancer drugs. CD243 is extensively distributed and expressed in the intestinal epithelium, in liver cells, in the cells of the proximal tubule of the kidney and in the capillary endothelial cells composing the blood-brain barrier and blood-testis barrier. It is also expressed on hematopoietic stem cells, T cells, B cells, and NK cells as well as on many multidrug resistant neoplastic cells.
Additional information: Clone REA495 displays negligible binding to Fc receptors.

Alternative names

ABCB1, ABC20, CLCS, GP170, MDR-1, P-GP, PGY1

Technical specifications

  • Antigen: CD243 (ABCB1)
  • Clone: REA495
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: ABCB1, ABC20, CLCS, GP170, MDR-1, P-GP, PGY1
  • Entrez Gene ID: 5243
  • Molecular mass of antigen [kDa]: 142
  • Distribution of antigen: B cells, endothelial cells, hematopoietic stem cells, NK cells, T cells, small intestine, myeloid leukemia cells, bile duct, brain, breast, kidney, liver, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Chen, C. J. et al. (1986) Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell 47(7): 381-389
    2. Brambila-Tapia, A. J. (2013) MDR1 (ABCB1) polymorphisms: functional effects and clinical implications. Rev Invest Clin 65(5): 445-454
    3. Yao, W. et al. (2014) CD243 gene polymorphism significantly associated with breast cancer susceptibility. Tumour Biol 35(8): 8017-8022
Product options: 12
130-107-529

CD243 (ABCB1)-VioBright FITC, human

for 30
tests
(1)
DKK 1.000,00 
130-107-476

CD243 (ABCB1)-VioBright FITC, human

for 100
tests
(1)
DKK 2.400,00 
130-107-525

CD243 (ABCB1)-PE, human

for 30
tests
(1)
DKK 900,00 
130-107-472

CD243 (ABCB1)-PE, human

for 100
tests
(1)
DKK 2.200,00 
130-107-526

CD243 (ABCB1)-APC, human

for 30
tests
(1)
DKK 900,00 
130-107-473

CD243 (ABCB1)-APC, human

for 100
tests
(1)
DKK 2.200,00 
130-107-527

CD243 (ABCB1)-PE-Vio770, human

for 30
tests
(1)
DKK 1.000,00 
130-107-474

CD243 (ABCB1)-PE-Vio770, human

for 100
tests
(1)
DKK 2.400,00 
130-107-528

CD243 (ABCB1)-APC-Vio770, human

for 30
tests
(1)
DKK 1.000,00 
130-107-475

CD243 (ABCB1)-APC-Vio770, human

for 100
tests
(1)
DKK 2.400,00 
130-107-524

CD243 (ABCB1)-Biotin, human

for 30
tests
(1)
DKK 750,00 
130-107-471

CD243 (ABCB1)-Biotin, human

for 100
tests
(1)
DKK 1.850,00