CD191 (CCR1) antibodies, human

CD191 (CCR1) antibodies, human

Clone: REA158 | Dilution: 1:11
Clone REA158 recognizes CCR1, a chemokine receptor that binds to CC subgroup of chemokines as ligands. Chemokines are small chemoattractant protein molcules and are subdivided into families CC, CXC, or CX3C.Chemokines exert their action via binding to corresponding chemokine receptors, which are G protein–coupled receptors and share several structural features. CCR1 binds chemokines auch as CCL3, CCL5, CCL7, and CCL14 as ligands. Expression of CCR1 is found on macrophages, natural killer cells, T cells, DC, monocytes, basophils, and eosinophils, where regulated CCR1 expression can be achieved by molecules such as IL2 and TGF-β2. CCR1-ligand interaction plays role in leukocyte migration, cell differentiation/activation and immune response.
Additional information: Clone REA158 displays negligible binding to Fc receptors.      

Alternative names

CCR1, CKR-1, CMKBR1, HM145, MIP1aR, SCYAR1

Technical specifications

  • Antigen: CD191 (CCR1)
  • Clone: REA158
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CCR1, CKR-1, CMKBR1, HM145, MIP1aR, SCYAR1
  • Entrez Gene ID: 1230
  • Molecular mass of antigen [kDa]: 41
  • Distribution of antigen: macrophages, monocytes, NK cells, T cells, basophils, eosinophils
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: Biotin, PE, APC, PE-Vio770

Specificity

In order to compare the epitope specificity of REAfinity Clone REA158 with other known clones, a competition assay was performed. 
 Cells were incubated with an excess of purified unconjugated REAfinity Antibody followed by staining with fluorochrome-conjugated antibodies of other known clones against the same marker. Based on the fluorescence signal obtained, the clones were identified as recognizing completely overlapping (++), partially overlapping (+), or completely different epitopes (-) of the marker.
 

Other clonesOverlap in epitope recognition with REA158
5F10329-
53504++
  • Selected references

    1. Ness, T. L. et al. (2004) CCR1 and CC chemokine ligand 5 interactions exacerbate innate immune responses during sepsis. J. Immunol. 173: 6938-6948
    2. Manzo, A. et al. (2003) Role of chemokines and chemokine receptors in regulating specific leukocyte trafficking in the immune/inflammatory response. Clin. Exp. Rheumatol. 21(4): 501-508
Product options: 8
130-100-368

CD191 (CCR1)-PE, human

for 30
tests
(1)
DKK 900,00 
130-100-367

CD191 (CCR1)-PE, human

for 100
tests
(1)
DKK 2.200,00 
130-100-360

CD191 (CCR1)-APC, human

for 30
tests
(1)
DKK 900,00 
130-100-358

CD191 (CCR1)-APC, human

for 100
tests
(1)
DKK 2.200,00 
130-100-372

CD191 (CCR1)-PE-Vio770, human

for 30
tests
(1)
DKK 1.000,00 
130-100-371

CD191 (CCR1)-PE-Vio770, human

for 100
tests
(1)
DKK 2.400,00 
130-105-097

CD191 (CCR1)-Biotin, human

for 30
tests
(1)
DKK 750,00 
130-105-067

CD191 (CCR1)-Biotin, human

for 100
tests
(1)
DKK 1.850,00