CD172a (SIRPα) antibodies, human

CD172a (SIRPα) antibodies, human

Clone: REA144 | Dilution: 1:11
Clone REA144 recognizes CD172a, which is also known as signal regulatory protein α (SIRPα). CD172a belongs to the Ig superfamily and is 75–110 kDa single-pass type I regulatory membrane protein. Expression of CD172a is found primarily on hematopoietic stem cells, neurons, and myeloid cells such as macrophages, monocytes, dendritic cells, granulocytes, and myeloid progenitors. CD172a phosphorylated at intracellular tyrosine sites, in response to extracellular stimuli, serves as the docking site for phosphatases such as SHP-1, SHP-2, or SHIP, which inturn desphosphorylate molecules involved in regulating various physiological effects. CD47 has been suggested as a ligand of CD172a.
Additional information: Clone REA144 displays negligible binding to Fc receptors.

Alternative names

SIRPα, Bit, Mfr, MYD-1, P84, Ptpns1, SHPS-1, Sirp

Technical specifications

  • Antigen: CD172a (SIRPα)
  • Clone: REA144
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: SIRPα, Bit, Mfr, MYD-1, P84, Ptpns1, SHPS-1, Sirp
  • Entrez Gene ID: 140885
  • Molecular mass of antigen [kDa]: 52
  • Distribution of antigen: macrophages, dendritic cells, myeloid cells, monocytes, hematopoietic stem cells, neurons, granulocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Motegi, S. et al. (2003) Role of the CD47-SHPS-1 system in regulation of cell migration. EMBO J. 22(11): 2634-2644
    2. Jung, C. J. et al. (2016) Comparative analysis of piggyBac, CRISPR/Cas9 and TALEN mediated BAC transgenesis in the zygote for the generation of humanized SIRPA rats. Sci. Rep. 6: 31455
    3. Oshima, K. et al. (2002) SHPS-1, a multifunctional transmembrane glycoprotein. FEBS Lett. 519(1-3): 1-7
Product options: 12
130-099-897

CD172a (SIRPα)-FITC, human

for 30
tests
(1)
DKK 750,00 
130-099-896

CD172a (SIRPα)-FITC, human

for 100
tests
(1)
DKK 1.850,00 
130-099-783

CD172a (SIRPα)-PE, human

for 30
tests
(1)
DKK 900,00 
130-099-781

CD172a (SIRPα)-PE, human

for 100
tests
(1)
DKK 2.200,00 
130-099-785

CD172a (SIRPα)-APC, human

for 30
tests
(1)
DKK 900,00 
130-099-784

CD172a (SIRPα)-APC, human

for 100
tests
(1)
DKK 2.200,00 
130-099-793

CD172a (SIRPα)-PE-Vio770, human

for 30
tests
(1)
DKK 1.000,00 
130-099-840

CD172a (SIRPα)-PE-Vio770, human

for 100
tests
(1)
DKK 2.400,00 
130-099-790

CD172a (SIRPα)-APC-Vio770, human

for 30
tests
(1)
DKK 1.000,00 
130-099-787

CD172a (SIRPα)-APC-Vio770, human

for 100
tests
(1)
DKK 2.400,00 
130-099-769

CD172a (SIRPα)-Biotin, human

for 30
tests
(1)
DKK 750,00 
130-099-768

CD172a (SIRPα)-Biotin, human

for 100
tests
(1)
DKK 1.850,00